ArticleBiophysical journal2008
Platelet adhesive dynamics. Part I: characterization of platelet hydrodynamic collisions and wall effects.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- The Effect of von Willebrand Disease on Platelet Adhesion Dynamics: Correlating a Multiscale Platelet Model to In Vitro Results.IEEE transactions on bio-medical engineering · 2026Article
- Multiscale simulations that incorporate patient-specific neural network models of platelet calcium signaling predict diverse thrombotic outcomes under flow.PLoS computational biology · 2025Article
- Exploring effects of platelet contractility on the kinetics, thermodynamics, and mechanisms of fibrin clot contraction.npj biological physics and mechanics · 2025Article
- Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation.International journal of molecular sciences · 2024Review
- Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots.Communications biology · 2023Article
- Image-based flow simulation of platelet aggregates under different shear rates.PLoS computational biology · 2023Article
- Biomechanical activation of blood platelets via adhesion to von Willebrand factor studied with mesoscopic simulations.Biomechanics and modeling in mechanobiology · 2023Article
- Computational Biomechanical Modeling of Fibrin Networks and Platelet-Fiber Network Interactions.Current opinion in biomedical engineering · 2022Article
- A three-dimensional multiscale model for the prediction of thrombus growth under flow with single-platelet resolution.PLoS computational biology · 2022Article
- A multiscale model for multiple platelet aggregation in shear flow.Biomechanics and modeling in mechanobiology · 2021Article
- The Art and Science of Building a Computational Model to Understand Hemostasis.Seminars in thrombosis and hemostasis · 2021Review
- A Multiscale Model for Recruitment Aggregation of Platelets by Correlating withCellular and molecular bioengineering · 2019Article
- Thrombosis in Cerebral Aneurysms and the Computational Modeling Thereof: A Review.Frontiers in physiology · 2018Review
- Effect of circulating tumor cell aggregate configuration on hemodynamic transport and wall contact.Mathematical biosciences · 2017Article
- Microfluidic measurement for blood flow and platelet adhesion around a stenotic channel: Effects of tile size on the detection of platelet adhesion in a correlation map.Biomicrofluidics · 2017Article
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- Evolution of Multivalent Nanoparticle Adhesion via Specific Molecular Interactions.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- The Effect of Hematocrit on Platelet Adhesion: Experiments and Simulations.Biophysical journal · 2016Article
- Minimum wound size for clotting: flowing blood coagulates on a single collagen fiber presenting tissue factor and von Willebrand factor.Integrative biology : quantitative biosciences from nano to macro · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Abnormally high shear stresses encountered in vivo induce spontaneous activation of blood platelets and formation of aggregates, even in the absence of vascular injury. A three-dimensional multiscale computational model-platelet adhesive dynamics-is developed and applied in Part I and Part II articles to elucidate key biophysical aspects of GPIbalpha-von-Willebrand-factor-mediated interplatelet binding that characterizes the onset of shear-induced platelet aggregation. In this article, the hydrodynamic effects of the oblate spheroidal shape of platelets and proximity of a plane wall on the nature of cell-cell collisions are systematically investigated. Physical quantities characterizing the adhesion probabilities between colliding platelet surfaces for the entire range of near-wall encounters between two platelets are obtained for application in platelet adhesive dynamics simulations of platelet aggregation explored in a companion article. The technique for matching simulation predictions of interplatelet binding efficiency to experimentally determined efficiencies is also described. Platelet collision behavior is found to be strikingly different from that of spheres, both close to and far from a bounding wall. Our results convey the significant effects that particle shape and presence of a bounding wall have on the particle trajectories and collision mechanisms, collision characteristics such as collision time and contact area, and collision frequency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.