ArticleBiophysical journal2008
Platelet adhesive dynamics. Part II: high shear-induced transient aggregation via GPIbalpha-vWF-GPIbalpha bridging.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Von Willebrand factor A1 blockade prevents platelet-mediated sustained occlusion for the treatment of arterial thrombosis.Communications biology · 2026Article
- A three-dimensional shear dependent continuum model of platelet aggregation under flow.PLoS computational biology · 2026Article
- The Effect of von Willebrand Disease on Platelet Adhesion Dynamics: Correlating a Multiscale Platelet Model to In Vitro Results.IEEE transactions on bio-medical engineering · 2026Article
- Genetic association of preeclampsia to von Willebrand factor and its size-regulator ADAMTS13.Research square · 2025Article
- Exploring effects of platelet contractility on the kinetics, thermodynamics, and mechanisms of fibrin clot contraction.npj biological physics and mechanics · 2025Article
- CD42-Enriched Extracellular Vesicles Contribute to Increased Platelet Aggregation and Possibly Organ Damage in Patients with Burn Injury Complicated by Sepsis.International journal of nanomedicine · 2025Article
- Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation.International journal of molecular sciences · 2024Review
- Decoding thrombosis through code: a review of computational models.Journal of thrombosis and haemostasis : JTH · 2024Review
- Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots.Communications biology · 2023Article
- Image-based flow simulation of platelet aggregates under different shear rates.PLoS computational biology · 2023Article
- Biomechanical activation of blood platelets via adhesion to von Willebrand factor studied with mesoscopic simulations.Biomechanics and modeling in mechanobiology · 2023Article
- A Multiscale Model for Shear-Mediated Platelet Adhesion Dynamics: Correlating In Silico with In Vitro Results.Annals of biomedical engineering · 2023Article
- Computational Biomechanical Modeling of Fibrin Networks and Platelet-Fiber Network Interactions.Current opinion in biomedical engineering · 2022Article
- Multiphysics and multiscale modeling of microthrombosis in COVID-19.PLoS computational biology · 2022Article
- Recent Advances in Computational Modeling of Biomechanics and Biorheology of Red Blood Cells in Diabetes.Biomimetics (Basel, Switzerland) · 2022Article
- Patient specific approach to analysis of shear-induced platelet activation in haemodialysis arteriovenous fistula.PloS one · 2022Article
- A three-dimensional multiscale model for the prediction of thrombus growth under flow with single-platelet resolution.PLoS computational biology · 2022Article
- In Vitro Measurements of Shear-Mediated Platelet Adhesion Kinematics as Analyzed through Machine Learning.Annals of biomedical engineering · 2021Article
- A multiscale model for multiple platelet aggregation in shear flow.Biomechanics and modeling in mechanobiology · 2021Article
- Rapid analysis of streaming platelet images by semi-unsupervised learning.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A three-dimensional multiscale computational model, platelet adhesive dynamics (PAD), is developed and applied in Part I and Part II articles to characterize and quantify key biophysical aspects of GPIbalpha-von-Willebrand-factor (vWF)-mediated interplatelet binding at high shear rates, a necessary and enabling step that initiates shear-induced platelet aggregation. In this article, an adhesive dynamics model of the transient aggregation of two unactivated platelets via GPIbalpha-vWF-GPIbalpha bridging is developed and integrated with the three-dimensional hydrodynamic flow model discussed in Part I. Platelet binding efficiencies predicted by PAD are in good agreement with platelet aggregation behavior observed experimentally, as documented in the literature. Deviations from average vWF ligand size or healthy GPIbalpha-vWF-A1 binding kinetics are observed in simulations to have significant effects on the dynamics of transient platelet aggregation, i.e., the efficiency of platelet aggregation and characteristics of bond failure, in ways that typify diseased conditions. The GPIbalpha-vWF-A1 bond formation rate is predicted to have piecewise linear dependence on the prevailing fluid shear rate, with a sharp transition in fluid shear dependency at 7200 s(-1). Interplatelet bond force-loading is found to be complex and highly nonlinear. These results demonstrate PAD as a powerful predictive modeling tool for elucidating platelet adhesive phenomena under flow.
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