ArticleBiophysical journal2008
The anomalous mole fraction effect in calcium channels: a measure of preferential selectivity.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Cleavage of N-terminus of polycystin-1 increases calcium permeability of polycystin-1/2 receptor channel complexes.JCI insight · 2025Article
- A Model Framework for Ion Channels with Selectivity Filters Based on Non-Equilibrium Thermodynamics.Entropy (Basel, Switzerland) · 2025Article
- Combined effect of confinement and dielectric exclusion on ion adsorption in slits, pores, and cavities.AIP advances · 2024Article
- Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations.The Journal of general physiology · 2023Article
- The Complex Proteolipidic Behavior of the SARS-CoV-2 Envelope Protein Channel: Weak Selectivity and Heterogeneous Oligomerization.International journal of molecular sciences · 2023Article
- Physics of the Nuclear Pore Complex: Theory, Modeling and Experiment.Physics reports · 2021Article
- Modeling the Device Behavior of Biological and Synthetic Nanopores with Reduced Models.Entropy (Basel, Switzerland) · 2020Article
- The mixture effect on ionic selectivity and permeability of nanotubes.Nanoscale advances · 2020Article
- Comparison of permeation mechanisms in sodium-selective ion channels.Neuroscience letters · 2019Review
- Selective ion permeation involves complexation with carboxylates and lysine in a model human sodium channel.PLoS computational biology · 2018Article
- The how and why of identifying the hair cell mechano-electrical transduction channel.Pflugers Archiv : European journal of physiology · 2015Review
- Cation Selectivity in Biological Cation Channels Using Experimental Structural Information and Statistical Mechanical Simulation.PloS one · 2015Article
- Sodium channel selectivity and conduction: prokaryotes have devised their own molecular strategy.The Journal of general physiology · 2014Article
- Interacting ions in biophysics: real is not ideal.Biophysical journal · 2013Review
- Ion correlations in nanofluidic channels: effects of ion size, valence, and concentration on voltage- and pressure-driven currents.Langmuir : the ACS journal of surfaces and colloids · 2013Article
- Current and selectivity in a model sodium channel under physiological conditions: Dynamic Monte Carlo simulations.Biochimica et biophysica acta · 2012Article
- Selectivity sequences in a model calcium channel: role of electrostatic field strength.European biophysics journal : EBJ · 2011Article
- Poisson-Nernst-Planck equations for simulating biomolecular diffusion-reaction processes II: size effects on ionic distributions and diffusion-reaction rates.Biophysical journal · 2011Article
- Analyzing the components of the free-energy landscape in a calcium selective ion channel by Widom's particle insertion method.The Journal of chemical physics · 2011Article
- Testing the applicability of Nernst-Planck theory in ion channels: comparisons with Brownian dynamics simulations.PloS one · 2011Article
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Authors and funding
2 authors.
Funding
Abstract
The cause of the anomalous mole fraction effect (AMFE) in calcium-selective ion channels is studied. An AMFE occurs when the conductance through a channel is lower in a mixture of salts than in the pure salts at the same concentration. The textbook interpretation of the AMFE is that multiple ions move through the pore in coordinated, single-file motion. Instead of this, we find that at its most basic level an AMFE reflects a channel's preferential binding selectivity for one ion species over another. The AMFE is explained by considering the charged and uncharged regions of the pore as electrical resistors in series: the AMFE is produced by these regions of high and low ion concentration changing differently with mole fraction due to the preferential ion selectivity. This is demonstrated with simulations of a model L-type calcium channel and a mathematical analysis of a simplistic point-charge model. The particle simulations reproduce the experimental data of two L-type channel AMFEs. Conditions under which an AMFE may be found experimentally are discussed. The resistors-in-series model provides a fundamentally different explanation of the AMFE than the traditional theory and does not require single filing, multiple occupancy, or momentum-correlated ion motion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.