ArticleNucleic acids research2008
DNA protection by histone-like protein HU from the hyperthermophilic eubacterium Thermotoga maritima.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- G-quadruplex structures in 16S rRNA regions correlate with thermal adaptation in prokaryotes.Nucleic acids research · 2025Article
- Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex.Cell research · 2024Article
- How Do Thermophiles Organize Their Genomes?Microbes and environments · 2024Review
- IHF and Fis asInternational journal of molecular sciences · 2023Review
- Isolation and Staining Reveal the Presence of Extracellular DNA in Marine Gel Particles.Gels (Basel, Switzerland) · 2023Article
- Enhanced binding of an HU homologue under increased DNA supercoiling preserves chromosome organisation and sustains Streptomyces hyphal growth.Nucleic acids research · 2022Article
- Structural and functional characterization of DdrC, a novel DNA damage-induced nucleoid associated protein involved in DNA compaction.Nucleic acids research · 2022Article
- Phosphorylation Regulation of a Histone-like HU Protein fromProtein and peptide letters · 2022Article
- Article
- DNA-Binding Properties of YbaB, a Putative Nucleoid-Associated Protein FromFrontiers in microbiology · 2021Article
- The DNA-binding protein HTa fromeLife · 2019Article
- HU ofFrontiers in microbiology · 2018Article
- A specific single-stranded DNA induces a distinct conformational change in the nucleoid-associated protein HU.Biochemistry and biophysics reports · 2016Article
- Bacterial histone-like proteins: roles in stress resistance.Current genetics · 2015Review
- Analysis of anoxybacillus genomes from the aspects of lifestyle adaptations, prophage diversity, and carbohydrate metabolism.PloS one · 2014Article
- Untwisting of the DNA helix stimulates the endonuclease activity of Bacillus subtilis Nth at AP sites.Nucleic acids research · 2012Article
- DNA condensation by TmHU studied by optical tweezers, AFM and molecular dynamics simulations.Journal of biological physics · 2011Article
- Mycobacterium tuberculosis nucleoid-associated DNA-binding protein H-NS binds with high-affinity to the Holliday junction and inhibits strand exchange promoted by RecA protein.Nucleic acids research · 2010Article
- The yeast high mobility group protein HMO2, a subunit of the chromatin-remodeling complex INO80, binds DNA ends.Nucleic acids research · 2009Article
- A functional type I topoisomerase from Pseudomonas aeruginosa.BMC molecular biology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In mesophilic prokaryotes, the DNA-binding protein HU participates in nucleoid organization as well as in regulation of DNA-dependent processes. Little is known about nucleoid organization in thermophilic eubacteria. We show here that HU from the hyperthermophilic eubacterium Thermotoga maritima HU bends DNA and constrains negative DNA supercoils in the presence of topoisomerase I. However, while binding to a single site occludes approximately 35 bp, association of T. maritima HU with DNA of sufficient length to accommodate multiple protomers results in an apparent shorter occluded site size. Such complexes consist of ordered arrays of protomers, as revealed by the periodicity of DNase I cleavage. Association of TmHU with plasmid DNA yields a complex that is remarkably resistant to DNase I-mediated degradation. TmHU is the only member of this protein family capable of occluding a 35 bp nonspecific site in duplex DNA; we propose that this property allows TmHU to form exceedingly stable associations in which DNA flanking the kinks is sandwiched between adjacent proteins. We suggest that T. maritima HU serves an architectural function when associating with a single 35 bp site, but generates a very stable and compact aggregate at higher protein concentrations that organizes and protects the genomic DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.