ArticleDNA repair2008
The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae.
Article in DNA repair, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Apparent Epigenetic Meiotic Double-Strand-Break Disparity in Saccharomyces cerevisiae: A Meta-Analysis.Genetics · 2016Pooled it
- Epigenetic regulation during meiosis and crossover.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Review
- The Chromatin Landscape around DNA Double-Strand Breaks in Yeast and Its Influence on DNA Repair Pathway Choice.International journal of molecular sciences · 2023Review
- Unique and Shared Roles for Histone H3K36 Methylation States in Transcription Regulation Functions.Cell reports · 2020Article
- Cell-type-specific genomics reveals histone modification dynamics in mammalian meiosis.Nature communications · 2019Article
- Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots.Molecular and cellular biology · 2017Article
- Homodimeric PHD Domain-containing Rco1 Subunit Constitutes a Critical Interaction Hub within the Rpd3S Histone Deacetylase Complex.The Journal of biological chemistry · 2016Article
- Article
- Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II.Genetics · 2015Article
- Article
- A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.Nature communications · 2014Article
- The transcriptome landscape of early maize meiosis.BMC plant biology · 2014Article
- New paradigms for conserved, multifactorial, cis-acting regulation of meiotic recombination.Nucleic acids research · 2012Review
- The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1.Nucleic acids research · 2011Article
- Analysis of biological features associated with meiotic recombination hot and cold spots in Saccharomyces cerevisiae.PloS one · 2011Article
- Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping.PloS one · 2010Article
- Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway.The Journal of biological chemistry · 2010Article
- DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.PLoS genetics · 2010Article
- Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes.Molecular cell · 2010Article
- Nucleosome occupancy landscape and dynamics at mouse recombination hotspots.EMBO reports · 2010Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The rate of meiotic recombination in the yeast Saccharomyces cerevisiae varies widely in different regions of the genome with some genes having very high levels of recombination (hotspots). A variety of experiments done in yeast suggest that hotspots are a feature of chromatin structure rather than a feature of primary DNA sequence. We examined the effects of mutating a variety of enzymes that affect chromatin structure on the recombination activity of the well-characterized HIS4 hotspot including the Set2p and Dot1p histone methylases, the Hda1p and Rpd3p histone deacetylases, the Sin4p global transcription regulator, and a deletion of one of the two copies of the genes encoding histone H3-H4. Loss of Set2p or Rpd3p substantially elevated HIS4 hotspot activity, and loss of Hda1p had a smaller stimulatory effect; none of the other alterations had a significant effect. The increase of HIS4 hotspot activity in set2 and rpd3 strains is likely to be related to the recent finding that histone H3 methylation by Set2p directs deacetylation of histones by Rpd3p.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.