Evidence map›Paper›PMID 18514747›Full record

ReviewPhysiology & behavior2008

Salt craving: the psychobiology of pathogenic sodium intake.

Michael J Morris, Elisa S Na, Alan Kim Johnson

Open access · greenAbstract readReview
In one paragraph

Review in Physiology & behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 135 citations in OpenAlex.

  1. Article
  2. Article
  3. Ecological momentary assessment of meal context and food types contributing to salt intake at meals.The international journal of behavioral nutrition and physical activity · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Quality Properties ofFood science of animal resources · 2021
    Article
  11. Salt need needs investigation.The British journal of nutrition · 2020
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Salt Appetite, and the Influence of Opioids.Neurochemical research · 2018
    Review
  17. Article
  18. Article
  19. Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael J MorrisDepartment of Psychology, The University of Iowa, Iowa City, IA, 52242-1407, USA.
Elisa S Na
Alan Kim Johnson
University of Iowa · US

Funding

VASOPRESSIN IN CARDIOVASCULAR REGULATIONP01HL014388 · NHLBI · UNIVERSITY OF IOWA · PI ABBOUD, FRANCOIS M · 1985 to 2018
$40.3M
Neurobehavioral Control of Body Fluid Balance in MouseR01DK066086 · NIDDK · UNIVERSITY OF IOWA · PI JOHNSON, ALAN KIM · 2005 to 2009
$1.5M
Role of Parabrachial 5-HT in Thirst and Salt AppetiteR01HL057472 · NHLBI · UNIVERSITY OF IOWA · PI JOHNSON, ALAN KIM · 1997 to 2005
$1.0M
NHLBI NIH HHS HL14388NHLBI NIH HHS HL57472NHLBI NIH HHS P01 HL014388NHLBI NIH HHS R01 HL057472NIDDK NIH HHS DK66086NIDDK NIH HHS R01 DK066086
6 · The paper itself

Abstract

Ionic sodium, obtained from dietary sources usually in the form of sodium chloride (NaCl, common table salt) is essential to physiological function, and in humans salt is generally regarded as highly palatable. This marriage of pleasant taste and physiological utility might appear fortunate--an appealing taste helps to ensure that such a vital substance is ingested. However, the powerful mechanisms governing sodium retention and sodium balance are unfortunately best adapted for an environment in which few humans still exist. Our physiological and behavioral means for maintaining body sodium and fluid homeostasis evolved in hot climates where sources of dietary sodium were scarce. For many reasons, contemporary diets are high in salt and daily sodium intakes are excessive. High sodium consumption can have pathological consequences. Although there are a number of obstacles to limiting salt ingestion, high sodium intake, like smoking, is a modifiable behavioral risk factor for many cardiovascular diseases. This review discusses the psychobiological mechanisms that promote and maintain excessive dietary sodium intake. Of particular importance are experience-dependent processes including the sensitization of the neural systems underlying sodium appetite and the effects of sodium balance on hedonic state and mood. Accumulating evidence suggests that plasticity within the central nervous system as a result of experience with high salt intake, sodium depletion, or a chronic unresolved sodium appetite fosters enduring changes in sodium related appetitive and consummatory behaviors.

Indexed as

AnimalsAppetiteAppetite RegulationAppetitive BehaviorEatingFeeding BehaviorHumansHypothalamusMotivationNutritional RequirementsRatsRewardSodium, DietaryTasteSodium, Dietary

Identifiers

PMID18514747
PMCPMC2491403
OpenAlexW2008419310

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.