ReviewRespiratory physiology & neurobiology2008
Airway smooth muscle and bronchospasm: fluctuating, fluidizing, freezing.
Review in Respiratory physiology & neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Psychosocial factors and behavioral medicine interventions in asthma.Journal of consulting and clinical psychology · 2013Pooled it
- Tissue traction microscopy to quantify muscle contraction within precision-cut lung slices.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins.Frontiers in pharmacology · 2020Article
- Asthma: A Loss of Post-natal Homeostatic Control of Airways Smooth Muscle With Regression Toward a Pre-natal State.Frontiers in pediatrics · 2020Review
- Airway Transmural Pressures in an Airway Tree During Bronchoconstriction in Asthma.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- The effect of obesity on lung function.Expert review of respiratory medicine · 2018Review
- Transient stretch induces cytoskeletal fluidization through the severing action of cofilin.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- A novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models.Scientific reports · 2016Article
- Can breathing-like pressure oscillations reverse or prevent narrowing of small intact airways?Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Phenotype, endotype and patient-specific computational modelling for optimal treatment design in asthma.Drug discovery today. Disease models · 2015Article
- Airway and Extracellular Matrix Mechanics in COPD.Frontiers in physiology · 2015Review
- Effectiveness of a load-imposing device for cyclic stretching of isolated human bronchi: a validation study.PloS one · 2015Article
- Nonlinear compliance modulates dynamic bronchoconstriction in a multiscale airway model.Biophysical journal · 2014Article
- Emergence of airway smooth muscle mechanical behavior through dynamic reorganization of contractile units and force transmission pathways.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- A computational model of the response of adherent cells to stretch and changes in substrate stiffness.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Tidal stretches differently regulate the contractile and cytoskeletal elements in intact airways.PloS one · 2014Article
- Can tidal breathing with deep inspirations of intact airways create sustained bronchoprotection or bronchodilation?Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Illuminating human health through cell mechanics.Swiss medical weekly · 2013Review
- A multi-scale approach to airway hyperresponsiveness: from molecule to organ.Frontiers in physiology · 2012Article
- Airway responsiveness to psychological processes in asthma and health.Frontiers in physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
We review here four recent findings that have altered in a fundamental way our understanding of airways smooth muscle (ASM), its dynamic responses to physiological loading, and their dominant mechanical role in bronchospasm. These findings highlight ASM remodeling processes that are innately out-of-equilibrium and dynamic, and bring to the forefront a striking intersection between topics in condensed matter physics and ASM cytoskeletal biology. By doing so, they place in a new light the role of enhanced ASM mass in airway hyper-responsiveness as well as in the failure of a deep inspiration to relax the asthmatic airway. These findings have established that (i) ASM length is equilibrated dynamically, not statically; (ii) ASM dynamics closely resemble physical features exhibited by so-called soft glassy materials; (iii) static force-length relationships fail to describe dynamically contracted ASM states; (iv) stretch fluidizes the ASM cytoskeleton. Taken together, these observations suggest that at the origin of the bronchodilatory effect of a deep inspiration, and its failure in asthma, may lie glassy dynamics of the ASM cell.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.