Evidence map›Paper›PMID 18514359›Full record

ArticleTrends in genetics : TIG2008

Tinker where the tinkering's good.

Matthew V Rockman, David L Stern

Open access · greenAbstract read
In one paragraph

Article in Trends in genetics : TIG, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Matthew V RockmanDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA.
David L Stern
Princeton University · US

Funding

The molecular basis of morphological evolutionR01GM063622 · NIGMS · PRINCETON UNIVERSITY · PI STERN, DAVID L · 2001 to 2010
$2.6M
NIGMS NIH HHS R01 GM063622
6 · The paper itself

Abstract

Do general principles govern the genetic causes of phenotypic evolution? One promising idea is that mutations in cis-regulatory regions play a predominant role in phenotypic evolution because they can alter gene activity without causing pleiotropic effects. Recent evidence that revealed the genetic basis of pigmentation pattern evolution in Drosophila santomea supports this notion. Multiple mutations that disrupt an abdominal enhancer of the pleiotropic gene tan partly explain the reduced pigmentation observed in this species.

Indexed as

Biological EvolutionAbdomenAnimalsDrosophila melanogasterGenes, InsectMutationPhenotypePigmentation

Identifiers

PMID18514359
PMCPMC2887039
OpenAlexW2171459263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.