ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2008
Incidence and risk factors for hepatitis C infection in a cohort of women in rural Egypt.
Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Characterizing hepatitis C virus epidemiology in Egypt: systematic reviews, meta-analyses, and meta-regressions.Scientific reports · 2018Pooled it
- The epidemiology of hepatitis C virus in Egypt: a systematic review and data synthesis.BMC infectious diseases · 2013Pooled it
- Article
- Elevated Concentration of Defensins in Hepatitis C Virus-Infected Patients.Journal of immunology research · 2016Article
- Epidemiology of hepatitis C virus exposure in Egypt: Opportunities for prevention and evaluation.World journal of hepatology · 2015Article
- Hepatitis C genotype 4: The past, present, and future.World journal of hepatology · 2015Review
- Estimation of hepatitis C virus infections resulting from vertical transmission in Egypt.Hepatology (Baltimore, Md.) · 2015Article
- Spatial epidemiology of hepatitis C virus infection in Egypt: analyses and implications.Hepatology (Baltimore, Md.) · 2014Article
- Potential for human immunodeficiency virus parenteral transmission in the Middle East and North Africa: an analysis using hepatitis C virus as a proxy biomarker.World journal of gastroenterology · 2014Review
- Screening the anti infectivity potentials of native N- and C-lobes derived from the camel lactoferrin against hepatitis C virus.BMC complementary and alternative medicine · 2014Article
- The Association between Female Genital Cutting and Spousal HCV Infection in Egypt.International journal of hepatology · 2014Article
- Reexamination of the relationship between the prevalence of hepatitis C virus and parenteral antischistosomal therapy among Egyptians resident in Qatar.Clinical and experimental gastroenterology · 2014Article
- Liver fibrosis staging through a stepwise analysis of non-invasive markers (FibroSteps) in patients with chronic hepatitis C infection.Liver international : official journal of the International Association for the Study of the Liver · 2013Article
- Article
- Hepatitis C virus-specific cell-mediated immune responses in children born to mothers infected with hepatitis C virus.The Journal of pediatrics · 2013Article
- Case control study to identify risk factors for acute hepatitis C virus infection in Egypt.BMC infectious diseases · 2012Article
- Hepatitis C virus genotype 4 with normal transaminases: histological changes, schistosomiasis and response to treatment.Journal of viral hepatitis · 2011Article
- Evidence of intense ongoing endemic transmission of hepatitis C virus in Egypt.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Prospective study of prevalence and risk factors for hepatitis C in pregnant Egyptian women and its transmission to their infants.Croatian medical journal · 2010Article
- Incidence and risk factors for community-acquired hepatitis C infection from birth to 5 years of age in rural Egyptian children.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2010Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
A prospective cohort study of the incidence and risk factors for hepatitis C virus (HCV) infection was performed in 2171 pregnant women in three rural Egyptian villages who were HCV antibody (anti-HCV) and RNA (HCV-RNA) negative at baseline. During an average of 2.2 years follow up, 25 incident cases were observed, giving an estimated HCV incidence of 5.2/1000 person-years (PY). The infection rate correlated with community anti-HCV prevalence in pregnant women, while the perinatal incidence rate of 11.2/1000 PY was almost five times that of the non-perinatal rate (2.3/1000 PY). The data suggested iatrogenic perinatal risk factors were associated with infection in one village, while health education reduced infections in another. Among the 25 incident cases, eight were HCV-RNA negative when they were first found to be anti-HCV positive and one-third of the 15 viraemic cases with follow-up data available cleared their HCV-RNA after an average of 1.3 years. None of the 25 incident cases were jaundiced or had symptoms of hepatitis but elevated serum alanine aminotransferase levels confirmed hepatitis in nine. Our data suggest that asymptomatic HCV infections frequently occurred during the perinatal period but often cleared and that educating medical personnel on safe practices possibly reduced HCV transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.