ReviewJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Assessment of coronary flow reserve using single photon emission computed tomography with technetium 99m-labeled tracers.
Review in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Quantitative SPECT/CT: Technique and Clinical Applications.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Myocardial perfusion reserve by using CZT: It's a long way to the top if you wanna standardize.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Quantification of myocardial flow reserve using a gamma camera with solid-state cadmium-zinc-telluride detectors: Relation to angiographic coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- The role of resting myocardial blood flow and myocardial blood flow reserve as a predictor of major adverse cardiovascular outcomes.PloS one · 2020Article
- Clinical decision support systems in myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Review
- Recurrent angina after coronary angioplasty: mechanisms, diagnostic and therapeutic options.European heart journal. Acute cardiovascular care · 2012Article
- Multimodality imaging in interventional cardiology.Nature reviews. Cardiology · 2012Review
- Incremental prognostic value of coronary flow reserve assessed with single-photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Article
- Reduced coronary flow reserve in patients with primary hyperparathyroidism: a study by G-SPECT myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2010Article
- Noninvasive quantification of coronary endothelial function by SPECT imaging in children with a history of Kawasaki disease.European journal of nuclear medicine and molecular imaging · 2010Article
- A fast cardiac gamma camera with dynamic SPECT capabilities: design, system validation and future potential.European journal of nuclear medicine and molecular imaging · 2010Article
- Measurement of coronary flow reserve by noninvasive cardiac imaging.European journal of nuclear medicine and molecular imaging · 2010Article
- Assessment of the arterial input function for estimation of coronary flow reserve by single photon emission computed tomography: comparison of two different approaches.European journal of nuclear medicine and molecular imaging · 2009Article
- Advances in quantitative assessment of myocardial blood flow and coronary reserve.European journal of nuclear medicine and molecular imaging · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
The quantitative assessment of coronary flow reserve (CFR) may be useful for the functional evaluation of coronary artery disease (CAD), allowing judgment of its severity, tracking of disease progression, and evaluation of the anti-ischemic efficacy of therapeutic strategies. Invasive techniques, such as intracoronary Doppler ultrasound and the pressure-derived method, which directly assess CFR velocity and fractional flow reserve, have been used for the evaluation of the physiologic significance of coronary lesions. Considerable progress has been made in the improvement of technologies directed toward the noninvasive quantification of myocardial blood flow and CFR. Positron emission tomography has emerged as an accurate technique to quantify CFR. The absolute measurements obtained with this noninvasive approach have been widely validated. Nevertheless, it has not been applied to routine studies because of its high cost and complexity. On the other hand, technetium 99m-labeled tracers have been largely used for the evaluation of myocardial perfusion with single photon emission computed tomography (SPECT) imaging in patients with suspected or known CAD. Recently, attempts to estimate CFR with SPECT tracers have been made to obtain, with noninvasive methods, data for quantitative functional assessment of CAD. This review analyzes the relative merit and limitations of CFR measurements by cardiac SPECT imaging with Tc-99m-labeled tracers and describes the potential clinical applications of this technique.
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