ArticleBMC genomics2008
Insights and inferences about integron evolution from genomic data.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Dominance ofMicrobial genomics · 2023Article
- Article
- IntegronFinder 2.0: Identification and Analysis of Integrons across Bacteria, with a Focus on Antibiotic Resistance in Klebsiella.Microorganisms · 2022Article
- Metagenomic strategies identify diverse integron-integrase and antibiotic resistance genes in the Antarctic environment.MicrobiologyOpen · 2021Article
- Article
- Class 1 integrons are low-cost structures in Escherichia coli.The ISME journal · 2017Article
- Identification and analysis of integrons and cassette arrays in bacterial genomes.Nucleic acids research · 2016Article
- The evolutionary dynamics of integrons in changing environments.The ISME journal · 2016Article
- Resistance integrons: class 1, 2 and 3 integrons.Annals of clinical microbiology and antimicrobials · 2015Review
- Integron diversity in marine environments.Environmental science and pollution research international · 2015Review
- Integrons: past, present, and future.Microbiology and molecular biology reviews : MMBR · 2014Review
- Genome sequence of Xanthomonas fuscans subsp. fuscans strain 4834-R reveals that flagellar motility is not a general feature of xanthomonads.BMC genomics · 2013Article
- Analysis of hydrocarbon-contaminated groundwater metagenomes as revealed by high-throughput sequencing.Molecular biotechnology · 2013Article
- Costly Class-1 integrons and the domestication of the the functional integrase.Mobile genetic elements · 2013Article
- Association between the presence of class 1 integrons, virulence genes, and phylogenetic groups of Escherichia coli isolates from river water.Microbial ecology · 2013Article
- A trade-off between the fitness cost of functional integrases and long-term stability of integrons.PLoS pathogens · 2012Article
- Article
- Class 1 integron in staphylococci.Molecular biology reports · 2011Review
- Marine integrons containing novel integrase genes, attachment sites, attI, and associated gene cassettes in polluted sediments from Suez and Tokyo Bays.The ISME journal · 2011Article
- Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons.Mobile DNA · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntegrons are mechanisms that facilitate horizontal gene transfer, allowing bacteria to integrate and express foreign DNA. These are important in the exchange of antibiotic resistance determinants, but can also transfer a diverse suite of genes unrelated to pathogenicity. Here, we provide a systematic analysis of the distribution and diversity of integron intI genes and integron-containing bacteria.
resultsWe found integrons in 103 different pathogenic and non-pathogenic bacteria, in six major phyla. Integrons were widely scattered, and their presence was not confined to specific clades within bacterial orders. Nearly 1/3 of the intI genes that we identified were pseudogenes, containing either an internal stop codon or a frameshift mutation that would render the protein product non-functional. Additionally, 20% of bacteria contained more than one integrase gene. dN/dS ratios revealed mutational hotspots in clades of Vibrio and Shewanella intI genes. Finally, we characterized the gene cassettes associated with integrons in Methylobacillus flagellatus KT and Dechloromonas aromatica RCB, and found a heavy metal efflux gene as well as genes involved in protein folding and stability.
conclusionOur analysis suggests that the present distribution of integrons is due to multiple losses and gene transfer events. While, in some cases, the ability to integrate and excise foreign DNA may be selectively advantageous, the gain, loss, or rearrangment of gene cassettes could also be deleterious, selecting against functional integrases. Thus, such a high fraction of pseudogenes may suggest that the selective impact of integrons on genomes is variable, oscillating between beneficial and deleterious, possibly depending on environmental conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.