ArticleThe Journal of infectious diseases2008
Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987--2006.
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Genetic diversity, population structure, and drug resistance of Plasmodium falciparum in Kenya: a systematic review and meta-analysis.Malaria journal · 2025Pooled it
- Pooled it
- Efficacies of DHA-PPQ and AS/SP in patients with uncomplicated Plasmodium falciparum malaria in an area of an unstable seasonal transmission in Sudan.Malaria journal · 2017Trial
- Longitudinal and Cross-sectional Analyses of Asymptomatic HIV-1/Malaria Co-infection in Kisumu County, Kenya.The American journal of tropical medicine and hygiene · 2023Article
- Low-grade sulfadoxine-pyrimethamine resistance in Plasmodium falciparum parasites from Lubango, Angola.Malaria journal · 2016Article
- Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance.PLoS computational biology · 2016Article
- Monitoring antimalarial drug resistance: Applying lessons learned from the past in a fast-moving present.International journal for parasitology. Drugs and drug resistance · 2012Review
- Differences in selective pressure on dhps and dhfr drug resistant mutations in western Kenya.Malaria journal · 2012Article
- Drug-resistant malaria in Sudan: A review of evidence and scenarios for the future.Sudanese journal of paediatrics · 2012Review
- Identification of pyrimethamine- and chloroquine-resistant Plasmodium falciparum in Africa between 1984 and 1998: genotyping of archive blood samples.Malaria journal · 2011Article
- Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations.The Journal of infectious diseases · 2011Article
- The evolution of pyrimethamine resistant dhfr in Plasmodium falciparum of south-eastern Tanzania: comparing selection under SP alone vs SP+artesunate combination.Malaria journal · 2011Article
- Drug resistance maps to guide intermittent preventive treatment of malaria in African infants.Parasitology · 2011Review
- Antimalarial drug sensitivity profile of western Kenya Plasmodium falciparum field isolates determined by a SYBR Green I in vitro assay and molecular analysis.The American journal of tropical medicine and hygiene · 2011Article
- Molecular monitoring of resistant dhfr and dhps allelic haplotypes in Morogoro and Mvomero districts in south eastern Tanzania.African health sciences · 2011Article
- Multiple origins of Plasmodium falciparum dihydropteroate synthetase mutant alleles associated with sulfadoxine resistance in India.Antimicrobial agents and chemotherapy · 2011Article
- Induction of antimalaria immunity by pyrimethamine prophylaxis during exposure to sporozoites is curtailed by parasite resistance.Antimicrobial agents and chemotherapy · 2011Article
- Selective sweeps and genetic lineages of Plasmodium falciparum drug -resistant alleles in Ghana.The Journal of infectious diseases · 2011Article
- Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine.Malaria journal · 2010Article
- Transmission and cross-mating of high-level resistance Plasmodium falciparum dihydrofolate reductase haplotypes in The Gambia.The American journal of tropical medicine and hygiene · 2010Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
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Abstract
Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP) emerged in Plasmodium falciparum from Asia in the 1960s and subsequently spread to Africa. It is not known whether alleles that confer SP resistance also arose independently in Africa. We defined the coding region and microsatellite haplotypes of dhfr alleles in P. falciparum collected in Kilifi, Kenya, during 1987--2006, which spans the period when SP was first introduced. Isolates that carried a double-mutant or triple-mutant dhfr allele were detected at a low frequency, even during 1987--1988. Each of 2 double mutants carried a unique haplotype, and both were related to wild-type haplotypes from the same population. The number of isolates that carried a triple-mutant dhfr allele increased rapidly after introduction of SP and shared the haplotype of the triple mutant derived form Asia. We observed no triple-mutant alleles with haplotypes related to those of the Africa-derived wild-type and double-mutant alleles.
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