ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2008
General pattern of meiotic recombination in male dogs estimated by MLH1 and RAD51 immunolocalization.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 44 citations in OpenAlex.
- The crosstalk between telomeres and DNA repair mechanisms: an overview to mammalian somatic cells, germ cells, and preimplantation embryos.Journal of assisted reproduction and genetics · 2024Review
- DNA Organization along Pachytene Chromosome Axes and Its Relationship with Crossover Frequencies.International journal of molecular sciences · 2021Article
- Crossover Interference: Shedding Light on the Evolution of Recombination.Annual review of genetics · 2019Review
- The Genomic Landscape of Crossover Interference in the Desert TreeFrontiers in genetics · 2019Article
- Article
- Immunocytological analysis of meiotic recombination in two anole lizards (Squamata, Dactyloidae).Comparative cytogenetics · 2017Article
- Broad-scale recombination pattern in the primitive bird Rhea americana (Ratites, Palaeognathae).PloS one · 2017Article
- A Pedigree-Based Map of Recombination in the Domestic Dog Genome.G3 (Bethesda, Md.) · 2016Article
- Article
- Sex-specific recombination maps for individual macrochromosomes in the Japanese quail (Coturnix japonica).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
- Incomplete meiotic sex chromosome inactivation in the domestic dog.BMC genomics · 2015Article
- Strong artificial selection in domestic mammals did not result in an increased recombination rate.Molecular biology and evolution · 2015Article
- Combined fluorescent and electron microscopic imaging unveils the specific properties of two classes of meiotic crossovers.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Impact of Robertsonian translocation on meiosis and reproduction: an impala (Aepyceros melampus) model.Journal of applied genetics · 2014Article
- Meiotic recombination analyses of individual chromosomes in male domestic pigs (Sus scrofa domestica).PloS one · 2014Article
- Evolution of recombination in eutherian mammals: insights into mechanisms that affect recombination rates and crossover interference.Proceedings. Biological sciences · 2013Article
- New method for visualization of C-heterochromatin in synaptonemal complex spreads.Comparative cytogenetics · 2013Article
- Multiple independent evolutionary losses of XY pairing at meiosis in the grey voles.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Genome-wide crossover distribution in Arabidopsis thaliana meiosis reveals sex-specific patterns along chromosomes.PLoS genetics · 2011Article
- A comparative study of the recombination pattern in three species of Platyrrhini monkeys (primates).Chromosoma · 2011Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to estimate a general pattern of meiotic recombination in the domestic dog (Canis familiaris) using immunolocalization of MLH1, a mismatch repair protein of mature recombination nodules. We prepared synaptonemal complex (SC) spreads from 124 spermatocytes of three male dogs and mapped 4959 MLH1 foci along 4712 autosomes. The mean number of MLH1 foci for all autosomes was 40.0 foci per cell. Total recombination length of the male dog autosomal genome map was estimated as 2000 cM. A global pattern of MLH1 foci distribution along the autosomal bivalents was rather similar to that found in the mammals studied: a high frequency near the telomeres and a low frequency near the centromeres. An obligate MLH1 focus in the X-Y pairing region was usually located very close to Xp-Yq telomeres. The distances between MLH1 foci at autosomal bivalents were consistent with crossover interference. A comparison of the interference estimates coming from the distribution of MLH1 interfocus distances and RAD51/MLH1 focus ratio indicated a substantial variation between species in the strength of interference.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.