ReviewHuman genetics2008
Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics.
Review in Human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 97 citations in OpenAlex.
- Trial
- The Role of MASP1, MASP2, and Mannose-Binding Lectin in the Immune Response to Hepatitis B Vaccination in Infants.Vaccines · 2026Article
- Insights into human history and complex traits from the genomes of African populations.Molecular biology and evolution · 2026Review
- Systematic annotation and analysis of susceptibility genes associated with vaccine adverse events.BMC medical genomics · 2025Article
- Cancer immunotherapy clinical trials to support urgently needed access in low- and middle-income countries: a report from the SITC global access and impact committee.Journal for immunotherapy of cancer · 2025Review
- Single-cell transcriptomics reveals inter-ethnic variation in immune response to Falciparum malaria.American journal of human genetics · 2025Article
- Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues.Human genomics · 2025Review
- The subdued post-boost spike-directed secondary IgG antibody response in Ugandan recipients of the Pfizer-BioNTech BNT162b2 vaccine has implications for local vaccination policies.Frontiers in immunology · 2024Article
- No Association BetweenDiabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Article
- Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease.Frontiers in endocrinology · 2023Review
- The Spike Protein of SARS-coV2 19B (S) Clade Mirrors Critical Features of Viral Adaptation and Coevolution.Microorganisms · 2022Article
- African Genomic Medicine Portal: A Web Portal for Biomedical Applications.Journal of personalized medicine · 2022Article
- Simulation of African and non-African low and high coverage whole genome sequence data to assess variant calling approaches.Briefings in bioinformatics · 2021Article
- Breast cancer in sub-Saharan Africa: The current state and uncertain future.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Qualitative study of comprehension of heritability in genomics studies among the Yoruba in Nigeria.BMC medical ethics · 2020Article
- Article
- Good Fences Make Good Neighbors: Human Immunodeficiency Virus and Vascular Disease.Open forum infectious diseases · 2019Review
- Population genetic evidence for positive and purifying selection acting at the human IFN-γ locus in Africa.Genes and immunity · 2019Article
- Novel polymorphisms inGlobal health, epidemiology and genomics · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 13 institutions in 7 countries.
Funding
Abstract
Africa is the ultimate source of modern humans and as such harbors more genetic variation than any other continent. For this reason, studies of the patterns of genetic variation in African populations are crucial to understanding how genes affect phenotypic variation, including disease predisposition. In addition, the patterns of extant genetic variation in Africa are important for understanding how genetic variation affects infectious diseases that are a major problem in Africa, such as malaria, tuberculosis, schistosomiasis, and HIV/AIDS. Therefore, elucidating the role that genetic susceptibility to infectious diseases plays is critical to improving the health of people in Africa. It is also of note that recent and ongoing social and cultural changes in sub-Saharan Africa have increased the prevalence of non-communicable diseases that will also require genetic analyses to improve disease prevention and treatment. In this review we give special attention to many of the past and ongoing studies, emphasizing those in Sub-Saharan Africans that address the role of genetic variation in human disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.