ArticleEuropean journal of applied physiology2008
Changes of noradrenaline-induced contractility and gene expression in aorta of rats acclimated to heat in two different modes.
Article in European journal of applied physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 11 citations in OpenAlex.
- Salivary Immunoglobulin A Secretion and Polymeric Ig Receptor Expression in the Submandibular Glands Are Enhanced in Heat-Acclimated Rats.International journal of molecular sciences · 2020Article
- Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats.Nutrients · 2019Article
- Spontaneously hypertensive rats are sensitive to thoracic aorta damage induced by a hot and humid environment.Experimental and therapeutic medicine · 2017Article
- Heat acclimation and thirst in rats.Physiological reports · 2015Article
- Thoracic aorta vasoreactivity in rats under exhaustive exercise: effects of Lycium barbarum polysaccharides supplementation.Journal of the International Society of Sports Nutrition · 2013Article
- Proliferation of neuronal progenitor cells and neuronal differentiation in the hypothalamus are enhanced in heat-acclimated rats.Pflugers Archiv : European journal of physiology · 2009Article
- Involvement of neurogenesis in the hypothalamic area in establishing long-term heat acclimation in rats.Temperature (Austin, Tex.)Review
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
We investigated changes in responsiveness to noradrenaline (NA) and gene expression in aorta, and plasma nitrite/nitrate (NOx) levels in heat-acclimated rats. Male rats were exposed for 10 consecutive days to either 32 degrees C in the second half of the dark phase (HI) or to 32 degrees C constantly (HC). Controls were kept at 24 degrees C. After heat acclimation, thoracic aorta was excised and blood was taken in the first (Dark1) and second (Dark2) halves of the dark phase, and in the light phase. Contractile response to NA in HI was significantly depressed in Dark1 and Dark2, whereas in HC the contraction response to NA was significantly attenuated in all phases. Endothelial NO synthase (eNOS) mRNA expression was significantly enhanced in HI in Dark2. Inducible NOS mRNA was undetectable. mRNA expression of period2 was not modified by heat acclimation. Plasma NOx concentrations in HI were significantly elevated in Dark1 and Dark2, while in HC, the level was significantly raised in all phases. Our results suggest that in rats, heat acclimation improves distensibility of thoracic aorta due to attenuated responsiveness to NA, which might be attributable in part to an upregulated eNOS expression and an increase in circulating NO. The phases of the day when such changes occurred appear to be closely related to the periods when the animals were previously subjected to heat.
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