ArticleHistochemistry and cell biology2008
Hepatitis C virus budding at lipid droplet-associated ER membrane visualized by 3D electron microscopy.
Article in Histochemistry and cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Emerging role of lipophagy in liver disorders.Molecular and cellular biochemistry · 2024Review
- What role for cellular metabolism in the control of hepatitis viruses?Frontiers in immunology · 2022Review
- Lung epithelial endoplasmic reticulum and mitochondrial 3D ultrastructure: a new frontier in lung diseases.Histochemistry and cell biology · 2021Review
- Obesity and COVID-19: what makes obese host so vulnerable?Immunity & ageing : I & A · 2021Review
- Molecular profiling of lipid droplets inside HuH7 cells with Raman micro-spectroscopy.Communications biology · 2020Article
- Involvement of hepatic lipid droplets and their associated proteins in the detoxification of aflatoxin BToxicology reports · 2020Article
- Review
- Role of cleavage at the core-E1 junction of hepatitis C virus polyprotein in viral morphogenesis.PloS one · 2017Article
- Identification of novel RNA secondary structures within the hepatitis C virus genome reveals a cooperative involvement in genome packaging.Scientific reports · 2016Article
- Article
- Detergent-resistant membrane association of NS2 and E2 during hepatitis C virus replication.Journal of virology · 2015Article
- The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion.PloS one · 2015Article
- NS2 proteins of GB virus B and hepatitis C virus share common protease activities and membrane topologies.Journal of virology · 2014Article
- Hepatitis C virus NS4B targets lipid droplets through hydrophobic residues in the amphipathic helices.Journal of lipid research · 2013Article
- Interaction of hepatitis C virus core protein with janus kinase is required for efficient production of infectious viruses.Biomolecules & therapeutics · 2013Review
- Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein.PLoS pathogens · 2013Article
- Cytosolic phospholipase A2 gamma is involved in hepatitis C virus replication and assembly.Journal of virology · 2012Article
- Endocytic tubules regulated by Rab GTPases 5 and 11 are used for envelopment of herpes simplex virus.The EMBO journal · 2012Article
- Review
- Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly.PLoS pathogens · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms underlying hepatitis C virus (HCV) morphogenesis remain elusive, but lipid droplets have recently been shown to be important organelles for virus production. We investigated the interaction between HCV-like particles and lipid droplets by three-dimensional reconstructions of serial ultrathin electron microscopy sections of cells producing the HCV core protein. The budding of HCV-like particles was mostly initiated at membranes close to the lipid droplets rather than at membranes directly apposed to the lipid droplets. This may have important implications for our understanding of the complex relationship between HCV and lipids and may make easier to dissect out the HCV life cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.