Trial reportIntensive care medicine2008
Subject-ventilator synchrony during neural versus pneumatically triggered non-invasive helmet ventilation.
Trial report in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03137225 (Noninvasive NAVA Versus NIPPV in Low Birthweight Premature Infants), which is not on this map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Noninvasive NAVA Versus NIPPV in Low Birthweight Premature Infants
Who cites it
31 citing papers in PubMed, 94 citations in OpenAlex.
- Noninvasive Neurally Adjusted Ventilator Assist Ventilation in the Postoperative Period Produces Better Patient-Ventilator Synchrony but Not Comfort.Pulmonary medicine · 2020Trial
- New setting of neurally adjusted ventilatory assist for noninvasive ventilation by facial mask: a physiologic study.Critical care (London, England) · 2017Trial
- A diaphragmatic electrical activity-based optimization strategy during pressure support ventilation improves synchronization but does not impact work of breathing.Critical care (London, England) · 2017Trial
- Neurally adjusted ventilatory assist (NAVA) improves patient-ventilator interaction during non-invasive ventilation delivered by face mask.Intensive care medicine · 2012Trial
- Subject-ventilator synchrony during neural versus pneumatically triggered non-invasive helmet ventilation.Intensive care medicine · 2008Trial
- The new neural pressure support (NPS) mode and the helmet: did we find the dynamic duo?Journal of anesthesia, analgesia and critical care · 2024Article
- Estimation of transpulmonary driving pressure during synchronized mechanical ventilation using a single lower assist maneuver (LAM) in rabbits: a comparison to measurements made with an esophageal balloon.Critical care (London, England) · 2023Article
- Application of neurally adjusted ventilatory assist in ventilator weaning of infants ventilator weaning.Brain and behavior · 2021Article
- The use of head helmets to deliver noninvasive ventilatory support: a comprehensive review of technical aspects and clinical findings.Critical care (London, England) · 2021Review
- Information conveyed by electrical diaphragmatic activity during unstressed, stressed and assisted spontaneous breathing: a physiological study.Annals of intensive care · 2019Article
- Neurally adjusted ventilatory assist versus pressure support ventilation in patient-ventilator interaction and clinical outcomes: a meta-analysis of clinical trials.Annals of translational medicine · 2019Article
- Control of respiratory drive by extracorporeal COCritical care (London, England) · 2019Article
- Non-invasive mechanical ventilation in hypoxemic respiratory failure: Just a matter of the interface?Journal of thoracic disease · 2016Article
- Work of breathing using different interfaces in spontaneous positive pressure ventilation: helmet, face-mask, and endotracheal tube.Journal of anesthesia · 2016Article
- Health economic modeling of the potential cost saving effects of Neurally Adjusted Ventilator Assist.Therapeutic advances in respiratory disease · 2016Article
- Automated patient-ventilator interaction analysis during neurally adjusted non-invasive ventilation and pressure support ventilation in chronic obstructive pulmonary disease.Critical care (London, England) · 2014Article
- Lung protection during non-invasive synchronized assist versus volume control in rabbits.Critical care (London, England) · 2014Article
- An automated and standardized neural index to quantify patient-ventilator interaction.Critical care (London, England) · 2013Article
- Neurally adjusted ventilatory assist: letting the respiratory center take over control of ventilation.Intensive care medicine · 2013Article
- Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio.Intensive care medicine · 2013Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePatient-ventilator synchrony during non-invasive pressure support ventilation with the helmet device is often compromised when conventional pneumatic triggering and cycling-off were used. A possible solution to this shortcoming is to replace the pneumatic triggering with neural triggering and cycling-off-using the diaphragm electrical activity (EA(di)). This signal is insensitive to leaks and to the compliance of the ventilator circuit.
designRandomized, single-blinded, experimental study.
settingUniversity Hospital. PARTICIPANTS AND SUBJECTS: Seven healthy human volunteers.
interventionsPneumatic triggering and cycling-off were compared to neural triggering and cycling-off during NIV delivered with the helmet. MEASUREMENTS AND
resultsTriggering and cycling-off delays, wasted efforts, and breathing comfort were determined during restricted breathing efforts (<20% of voluntary maximum EA(di)) with various combinations of pressure support (PSV) (5, 10, 20 cm H(2)O) and respiratory rates (10, 20, 30 breath/min). During pneumatic triggering and cycling-off, the subject-ventilator synchrony was progressively more impaired with increasing respiratory rate and levels of PSV (p < 0.001). During neural triggering and cycling-off, effect of increasing respiratory rate and levels of PSV on subject-ventilator synchrony was minimal. Breathing comfort was higher during neural triggering than during pneumatic triggering (p < 0.001).
conclusionsThe present study demonstrates in healthy subjects that subject-ventilator synchrony, trigger effort, and breathing comfort with a helmet interface are considerably less impaired during increasing levels of PSV and respiratory rates with neural triggering and cycling-off, compared to conventional pneumatic triggering and cycling-off.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.