ArticleDer Internist2008
[27-year old pregnant woman with syncope and dyspnea after aortic alloplastic heart valve replacement 15 years ago].
Article in Der Internist, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Thrombolysis and thrombectomy in a first trimester stroke: expanding the evidence for acute ischemic stroke management in pregnancy. Illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Prosthetic tricuspid valve thrombosis: three case reports and literature review.The journal of Tehran Heart Center · 2012Article
- Tenecteplase in prosthetic mitral valve thrombosis.Journal of the Saudi Heart Association · 2011Article
- [Cumarines in pregnancy - critical appraisal].Der Internist · 2009Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 27-year old pregnant woman presented in our emergency department with syncope, dyspnea and complaints about an overall impairment. She had received aortic alloplastic heart valve replacement due to a congenital, valvular stenosis in 1993. We diagnosed a prosthetic heart valve thrombosis associated with cardiac decompensation. Due to tachycardia and critical hypotension we decided to perform fibrinolytic therapy with tenecteplase. After fibrinolysis both prosthetic heart valve leaflets were separating in normal and regular function. The patient was initially anticoagulated with low molecular weight heparin, which was switched during the hospital stay to unfractionated heparin. Later oral anticoagulation with phenprocoumon was initiated. At 36 weeks of gestation an uneventful elective abdominal caesarean section was performed. The mother and the newborn were in healthy condition. Hypercoaguability in pregnancy is a serious problem, especially for patients who already have an existing indication for therapeutic anticoagulation. Fibrinolysis should definitely be considered an option during pregnancy in critical and life-threatening situations.
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Registered trials
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