Evidence map›Paper›PMID 18512023›Full record

ReviewCancer metastasis reviews2008

The role of DNA synthesis imaging in cancer in the era of targeted therapeutics.

Sridhar Nimmagadda, Anthony F Shields

Open access · greenAbstract readReview
In one paragraph

Review in Cancer metastasis reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Molecular Imaging with 3'-deoxy-3'[(18)F]-Fluorothymidine (Diagnostics (Basel, Switzerland) · 2020
    Article
  2. Article
  3. Article
  4. PreliminaryContrast media & molecular imaging · 2017
    Article
  5. PET of Glucose Metabolism and Cellular Proliferation in Prostate Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016
    Review
  6. Imaging Cellular Proliferation in Prostate Cancer with Positron Emission Tomography.Asia Oceania journal of nuclear medicine & biology · 2015
    Review
  7. PET/CT in prostate cancer: non-choline radiopharmaceuticals.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2012
    Article
  8. Molecular imaging of prostate cancer: PET radiotracers.AJR. American journal of roentgenology · 2012
    Review
  9. Discriminant analysis of ¹⁸F-fluorothymidine kinetic parameters to predict survival in patients with recurrent high-grade glioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sridhar NimmagaddaRussel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA. snimmag1@jhmi.edu
Anthony F Shields
Johns Hopkins University · USThe Barbara Ann Karmanos Cancer Institute · US

Funding

LABELED THYMIDINE: DEVELOPMENT AS A PET IMAGING AGENTR01CA039566 · NCI · WAYNE STATE UNIVERSITY · PI SHIELDS, ANTHONY FRANK · 1985 to 2008
$2.8M
PET IMAGING OF DRUG KINETICS AND PATHWAYSR01CA083131 · NCI · WAYNE STATE UNIVERSITY · PI SHIELDS, ANTHONY FRANK · 1999 to 2002
$960k
NCI NIH HHS CA39566NCI NIH HHS CA 83131NCI NIH HHS R01 CA083131PHS HHS U24 92871
6 · The paper itself

Abstract

Non-specific targets such as DNA and microtubules have been the mainstay of cancer therapeutics and the most effective clinical agents until a decade ago. Advances in genetics, molecular and cellular biology over the past decade led to the development of a new generation of agents that are far more specific and effective. In contrast to progress seen with therapeutic agents, general monitoring targets such as proliferation imaging are just gaining momentum and targeted imaging is still in its infancy. In these paradoxical times, this review assesses the role of proliferation imaging in monitoring the efficacy of targeted therapeutics.

Indexed as

Cell ProliferationDNA ReplicationAnimalsDiagnostic ImagingHumansNeoplasmsPositron-Emission TomographyRadiopharmaceuticalsRadiopharmaceuticals

Identifiers

PMID18512023
PMCPMC3086165
OpenAlexW2044154482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.