ArticleAmerican journal of respiratory and critical care medicine2008
Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock.
Article in American journal of respiratory and critical care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Identification of a Four-Gene Signature for Diagnosing Paediatric Sepsis.BioMed research international · 2022Pooled it
- Global Case-Fatality Rates in Pediatric Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis.JAMA pediatrics · 2019Pooled it
- Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock.Critical care medicine · 2010Trial
- Interleukin-8 in health and disease.Molecular biomedicine · 2026Review
- Role of biomarkers in pediatric sepsis: What evidence says?World journal of clinical pediatrics · 2026Review
- Circulating granzyme A is elevated within the dysregulated host response and associates with mortality in abdominal sepsis.Frontiers in immunology · 2026Article
- Interleukin-8 Predicts Fatal Kala-Azar: A Case-Control Study.Tropical medicine and infectious disease · 2025Article
- Article
- Advances and Challenges in Pediatric Sepsis Diagnosis: Integrating Early Warning Scores and Biomarkers for Improved Prognosis.Biomolecules · 2025Review
- scCaT: An explainable capsulating architecture for sepsis diagnosis transferring from single-cell RNA sequencing.PLoS computational biology · 2024Article
- Predictive value of laboratory indicators for in-hospital death in children with community-onset sepsis: a prospective observational study of 266 patients.BMJ paediatrics open · 2024Observational
- Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans.Cell reports · 2024Article
- Liang-Ge-San: a classic traditional Chinese medicine formula, attenuates acute inflammation via targeting GSK3β.Frontiers in pharmacology · 2023Article
- Refining empiric subgroups of pediatric sepsis using machine-learning techniques on observational data.Frontiers in pediatrics · 2023Review
- Impact of Inherited Genetic Variants on Critically Ill Septic Children.Pathogens (Basel, Switzerland) · 2022Review
- Pediatric sepsis biomarkers for prognostic and predictive enrichment.Pediatric research · 2022Review
- Review
- The Autoimmune Risk R262W Variant of the Adaptor SH2B3 Improves Survival in Sepsis.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Establishment and validation of a logistic regression model for prediction of septic shock severity in children.Hereditas · 2021Article
- Reverse Engineering of the Pediatric Sepsis Regulatory Network and Identification of Master Regulators.Biomedicines · 2021Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleInterventional clinical trials involving children with septic shock would benefit from an efficient preenrollment stratification strategy.
objectivesTo test the predictive value of interleukin (IL)-8 for 28-day mortality in pediatric septic shock.
methodsA training data set (n = 40) identified a serum IL-8 of greater than 220 pg/ml as having a 75% sensitivity and specificity for predicting 28-day mortality. This cutoff was then subjected to a series of validation steps. MEASUREMENTS AND MAIN
resultsSubjects were drawn from two large, independent pediatric septic shock databases. Prospective application of the IL-8 cutoff to validation data set 1 (n = 139) demonstrated 78% sensitivity and 64% specificity for 28-day mortality. A serum IL-8 level of 220 pg/ml or less, however, had a negative predictive value for 28-day mortality of 95% in validation data set 1, which was subsequently applied to an independently generated data set of children with septic shock (validation set 2, n = 193). A serum IL-8 level of 220 pg/ml or less had a negative predictive value for 28-day mortality of 94% when applied to validation set 2.
conclusionsA serum IL-8 level of 220 pg/ml or less, obtained within 24 hours of admission, predicts a high likelihood of survival in children with septic shock. We propose that IL-8 can be used to exclude such patients from interventional clinical trials and ultimately derive a study population with a more favorable risk to benefit ratio when subjected to a study agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.