ArticleStem cells (Dayton, Ohio)2008
Diverse adult stem cells share specific higher-order patterns of gene expression.
Article in Stem cells (Dayton, Ohio), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
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- Tissue specific human fibroblast differential expression based on RNAsequencing analysis.BMC genomics · 2019Article
- The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile.PLoS biology · 2018Article
- Article
- Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over-expressed in cancer.The Journal of pathology · 2015Article
- The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation.The Journal of clinical investigation · 2013Article
- Comparison of the transcriptomes of long-term label retaining-cells and control cells microdissected from mammary epithelium: an initial study to characterize potential stem/progenitor cells.Frontiers in oncology · 2013Article
- SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype.Journal of molecular cell biology · 2012Article
- MIST1-a novel marker of plasmacytic differentiation.Applied immunohistochemistry & molecular morphology : AIMM · 2012Article
- Myeloid skewing in murine autoimmune arthritis occurs in hematopoietic stem and primitive progenitor cells.Blood · 2012Article
- Sorting mouse jejunal epithelial cells with CD24 yields a population with characteristics of intestinal stem cells.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Transcription factor MIST1 in terminal differentiation of mouse and human plasma cells.Physiological genomics · 2011Article
- Geminin cooperates with Polycomb to restrain multi-lineage commitment in the early embryo.Development (Cambridge, England) · 2011Article
- Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics.BMC genomics · 2010Article
- Decoded calreticulin-deficient embryonic stem cell transcriptome resolves latent cardiophenotype.Stem cells (Dayton, Ohio) · 2010Article
- Porcine skin-derived progenitor (SKP) spheres and neurospheres: Distinct "stemness" identified by microarray analysis.Cellular reprogramming · 2010Article
- RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.Molecular and cellular biology · 2010Article
- Growth factor regulation of prostaglandin-endoperoxide synthase 2 (Ptgs2) expression in colonic mesenchymal stem cells.The Journal of biological chemistry · 2010Article
- Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection.Cell host & microbe · 2009Article
- Regulation of mouse embryonic stem cell neural differentiation by retinoic acid.Developmental biology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Adult tissue stem cells (SCs) share functional properties regardless of their tissue of residence. It had been thought that SCs might also share expression of certain "stemness" genes, although early investigations for such genes were unsuccessful. Here, we show that SCs from diverse tissues do preferentially express certain types of genes and that SCs resemble other SCs in terms of global gene expression more than they resemble the differentiated cells (DCs) of the tissues that they supply. Genes associated with nuclear function and RNA binding were over-represented in SCs. In contrast, DCs from diverse tissues shared enrichment in genes associated with extracellular space, signal transduction, and the plasma membrane. Further analysis showed that transit-amplifying cells could be distinguished from both SCs and DCs by heightened expression of cell division and DNA repair genes and decreased expression of apoptosis-related genes. This transit-amplifying cell-specific signature was confirmed by de novo generation of a global expression profile of a cell population highly enriched for transit-amplifying cells: colonic crypt-base columnar cells responding to mucosal injury. Thus, progenitor cells preferentially express intracellular or biosynthetic genes, and differentiation correlates with increased expression of genes for interacting with other cells or the microenvironment. The higher-order, Gene Ontology term-based analysis we use to distinguish SC- and DC-associated gene expression patterns can also be used to identify intermediate differentiation states (e.g., that of transit-amplifying cells) and, potentially, any biological state that is reflected in changes in global gene expression patterns. Disclosure of potential conflicts of interest is found at the end of this article.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.