ArticleMolecular endocrinology (Baltimore, Md.)2008
Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells.
Article in Molecular endocrinology (Baltimore, Md.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Aquaporins as Prognostic Biomarker in Prostate Cancer.Cancers · 2023Review
- Differential Expressions of Aquaporin Subtypes in the Adult Mouse Testis.Development & reproduction · 2022Article
- PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma.Oncogenesis · 2020Article
- Physiological and pathological impact of AQP1 knockout in mice.Bioscience reports · 2019Review
- Single-Cell RNA Sequencing Reveals Novel Markers of Male Pituitary Stem Cells and Hormone-Producing Cell Types.Endocrinology · 2018Article
- Bumetanide Derivatives AqB007 and AqB011 Selectively Block the Aquaporin-1 Ion Channel Conductance and Slow Cancer Cell Migration.Molecular pharmacology · 2016Article
- Carboxypeptidase E and Secretogranin III Coordinately Facilitate Efficient Sorting of Proopiomelanocortin to the Regulated Secretory Pathway in AtT20 Cells.Molecular endocrinology (Baltimore, Md.) · 2016Article
- Involvement of AQP6 in the Mercury-sensitive osmotic lysis of rat parotid secretory granules.The Journal of membrane biology · 2013Article
- Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor β.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Probing the production of amidated peptides following genetic and dietary copper manipulations.PloS one · 2011Article
- Cellular and subcellular aquaporin-4 distribution in the mouse neurohypophysis and the effects of osmotic stimulation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Secretion stimulates intramembrane proteolysis of a secretory granule membrane enzyme.The Journal of biological chemistry · 2010Article
- Signaling from the secretory granule to the nucleus: Uhmk1 and PAM.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Hypotonicity-induced Renin exocytosis from juxtaglomerular cells requires aquaporin-1 and cyclooxygenase-2.Journal of the American Society of Nephrology : JASN · 2009Article
- Induction stage-dependent expression of vascular endothelial growth factor and aquaporin-1 in diethylstilbestrol-treated rat pituitary.European journal of histochemistry : EJH · 2009Review
- Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Structure, function and translational relevance of aquaporin dual water and ion channels.Molecular aspects of medicineReview
- Signaling from the secretory granule to the nucleus.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Aquaporins (AQPs), a family of water channels expressed in epithelial cells, function to transport water in a bidirectional manner to facilitate transepithelial fluid absorption and secretion. Additionally, AQP1 and AQP5 are found in pancreatic zymogen granules and synaptic vesicles and are involved in vesicle swelling and exocytosis in exocrine cells and neurons. Here, we show AQP1 is in dense-core secretory granule (DCSG) membranes of endocrine tissue: pituitary and adrenal medulla. The need for AQP1 in endocrine cell function was examined by stable transfection of AQP1 antisense RNA into AtT20 cells, a pituitary cell line, to down-regulate AQP1 expression. These AQP1-deficient cells showed more than 60% depletion of DCSGs and significantly decreased DCSG protein levels, including proopiomelanocotin/pro-ATCH and prohormone convertase 1/3, but not non-DCSG proteins. Pulse-chase studies revealed that whereas DCSG protein synthesis was unaffected, approximately 50% of the newly synthesized proopiomelanocortin was degraded within 1 h. Low levels of ACTH were released upon stimulation, indicating that the small number of DCSGs that were made in the presence of the residual AQP1 were functionally competent for exocytosis. Analysis of anterior pituitaries from AQP1 knockout mice showed reduced prohormone convertase 1/3, carboxypeptidase E, and ACTH levels compared to wild-type mice demonstrating that our results observed in AtT20 cells can be extended to the animal model. Thus, AQP1 is important for maintaining DCSG biogenesis and normal levels of hormone secretion in pituitary endocrine cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.