ArticleToxicological sciences : an official journal of the Society of Toxicology2008
MRP2 and the DMPS- and DMSA-mediated elimination of mercury in TR(-) and control rats exposed to thiol S-conjugates of inorganic mercury.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Therapeutic potential of traditional herbal plants and their polyphenols in alleviation of mercury toxicity.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Multidrug Resistance-Associated Proteins 3 and 5 Play a Role in the Hepatic Transport of Mercuric Conjugates of Glutathione.International journal of molecular sciences · 2025Article
- Using Small Molecules for Targeting Heavy Metals in Neurotoxicity and Neuroinflammation.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Proximal tubular transport of Metallothionein-Mercury complexes and protection against nephrotoxicity.Current research in toxicology · 2023Article
- The Herbal Constituents in An-Gong-Niu-Huang Wan (AGNH) Protect against Cinnabar- and Realgar-Induced Hepatorenal Toxicity and Accumulations of Mercury and Arsenic in Mice.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- A polysaccharide-peptide with mercury clearance activity from dried fruiting bodies of maitake mushroom Grifola frondosa.Scientific reports · 2018Article
- MRP2 and the Transport Kinetics of Cysteine Conjugates of Inorganic Mercury.Biological trace element research · 2018Article
- Exposure to mixtures of mercury, cadmium, lead, and arsenic alters the disposition of single metals in tissues of Wistar rats.Journal of toxicology and environmental health. Part A · 2018Article
- Xenobiotic transporters and kidney injury.Advanced drug delivery reviews · 2017Review
- Chronic Kidney Disease and Exposure to Nephrotoxic Metals.International journal of molecular sciences · 2017Review
- Oral exposure of pregnant rats to toxic doses of methylmercury alters fetal accumulation.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
- The aging kidney and the nephrotoxic effects of mercury.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- Mechanisms involved in the transport of mercuric ions in target tissues.Archives of toxicology · 2017Review
- Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice.Environmental health perspectives · 2016Article
- Compensatory renal hypertrophy and the handling of an acute nephrotoxicant in a model of aging.Experimental gerontology · 2016Article
- Is Challenge Testing Valid for Assessing Body Metal Burden?Integrative medicine (Encinitas, Calif.) · 2015Article
- Toxicological significance of renal Bcrp: Another potential transporter in the elimination of mercuric ions from proximal tubular cells.Toxicology and applied pharmacology · 2015Article
- Novel Hg2+-induced nephropathy in rats and mice lacking Mrp2: evidence of axial heterogeneity in the handling of Hg2+ along the proximal tubule.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Aging and the disposition and toxicity of mercury in rats.Experimental gerontology · 2014Article
- Chelation: harnessing and enhancing heavy metal detoxification--a review.TheScientificWorldJournal · 2013Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cysteine (Cys) and homocysteine (Hcy)-S-conjugates of inorganic mercury (Hg2+) are transportable species of Hg2+ that are taken up readily by proximal tubular cells. The metal chelators, 2,3-dimercaptopropane-1-sulfonic acid (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA), have been used successfully to extract Hg2+ from these cells, presumably via the multidrug resistance protein (Mrp2). In the current study, we tested the hypothesis that Mrp2 is involved in the DMPS- and DMSA-mediated extraction of Hg2+ following administration of Hg2+ as an S-conjugate of Cys or Hcy. To test this hypothesis, control and TR(-) (Mrp2-deficient) rats were injected with 0.5 micromol/kg HgCl2 (containing 203Hg2+) conjugated to 1.25 micromol/kg Cys or Hcy. After 24 and 28 h, rats were treated with saline or 100 mg/kg DMPS or DMSA. Tissues were harvested 48 h after Hg2+ exposure. The renal and hepatic burden of Hg2+ was greater in saline-injected TR- rats than in corresponding controls. Accordingly, the content of Hg2+ in the urine and feces was less in TR- rats than in controls. Following treatment with DMPS or DMSA, the renal content of Hg2+ in both groups of rats was reduced significantly and the urinary excretion of Hg2+ was increased. In liver, the effect of each chelator appeared to be dependent upon the form in which Hg2+ was administered. In vitro experiments provide direct evidence indicating that DMPS and DMSA-S-conjugates of Hg2+ are substrates for Mrp2. Overall, these data support our hypothesis that Mrp2 is involved in the DMPS and DMSA-mediated extraction of the body burden of Hg2+.
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