ArticleInternational immunology2008
ICAT expression disrupts beta-catenin-TCF interactions and impairs survival of thymocytes and activated mature T cells.
Article in International immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities.Genes & diseases · 2024Review
- ICAT promotes colorectal cancer metastasis via binding to JUP and activating the NF-κB signaling pathway.Journal of clinical laboratory analysis · 2022Article
- The WNT/β-catenin dependent transcription: A tissue-specific business.WIREs mechanisms of disease · 2021Review
- Long noncoding RNAAutophagy · 2020Article
- TCF/LEF dependent and independent transcriptional regulation of Wnt/β-catenin target genes.The EMBO journal · 2019Article
- Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed ß-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift.Virchows Archiv : an international journal of pathology · 2017Article
- Temporal regulation of Wnt/β-catenin signaling is important for invariant NKT cell development and terminal maturation.Molecular immunology · 2017Article
- Wnt Signaling: Role in Regulation of Haematopoiesis.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2016Review
- Article
- β-catenin/TCF-1 pathway in T cell development and differentiation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Review
- Review
- T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.Clinical and experimental gastroenterology · 2011Article
- Wnt/beta-catenin signaling in T-cell immunity and cancer immunotherapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Review
- Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- TCF1 and beta-catenin regulate T cell development and function.Immunologic research · 2010Review
- The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage.Nature immunology · 2010Article
- Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma.Nature immunology · 2009Article
- Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell development.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
T cell factor (TCF) family of transcription factors and beta-catenin critically regulate T cell development as demonstrated by the deletion of the tcf gene, which results in a block early in development that becomes complete in mice bearing tcf/lef double deletion. However, the role of beta-catenin, a major TCF cofactor, remains controversial. To directly address this, we have generated transgenic mice expressing Inhibitor of beta-catenin and TCF (ICAT), a naturally occurring inhibitor that specifically disrupts TCF and beta-catenin interactions. In this report, we demonstrate that disrupting the interaction of beta-catenin with TCF renders adult thymocytes and activated T cells highly susceptible to apoptosis. In contrast to previously reported observations during fetal thymocyte development, these data show that in adult mice, survival and not differentiation of thymocytes, depends on transcription by TCF and beta-catenin. Indeed, we demonstrate that expression of ICAT impedes thymocyte survival by reducing the expression of Bcl(xL) in thymocytes below a critical threshold. Survival of activated mature T cells was also impaired due to diminished expression of activation-induced Bcl(xL). Accordingly, expression of transgenic Bcl-2 rescued activated ICAT-Tg CD4 T cells from apoptosis. Thus, disruption of TCF-beta-catenin interactions specifically impairs the survival of thymocytes and activated T cells.
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