ReviewJournal of dermatological science2008
Genetically engineered mouse models for skin research: taking the next step.
Review in Journal of dermatological science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Self-Assembled Skin Equivalents with Monoclonal CRISPR/Cas9-Modified N/TERT-1 Keratinocytes: A Cutting-Edge Model for Human Skin and its Diseases.Advanced healthcare materials · 2026Article
- Experimental Models for the Study of Hereditary Cornification Defects.Biomedicines · 2021Review
- Bench approaches to study the detrimental cutaneous impact of tropospheric ozone.Journal of exposure science & environmental epidemiology · 2021Review
- Animal Models for Studies of Keloid Scarring.Advances in wound care · 2019Review
- Chemically induced skin carcinogenesis: Updates in experimental models (Review).Oncology reports · 2016Review
- Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75.The Journal of investigative dermatology · 2016Article
- Transgenic mouse technology in skin biology: generation of knockin mice.The Journal of investigative dermatology · 2014Article
- Genomic organization, transcriptomic analysis, and functional characterization of avian α- and β-keratins in diverse feather forms.Genome biology and evolution · 2014Article
- Animal models of skin disease for drug discovery.Expert opinion on drug discovery · 2013Review
- Progress towards genetic and pharmacological therapies for keratin genodermatoses: current perspective and future promise.Experimental dermatology · 2012Review
- Mouse models for unraveling the importance of diet in colon cancer prevention.The Journal of nutritional biochemistry · 2010Review
- Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications.Nature protocols · 2009Article
- Article
- Murine Skin Carcinogenesis and the Role of Immune System Dysregulation in the Tumorigenicity of 2-Ethylhexyl Acrylate.Biomedicine hubReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Genetically engineered mouse models are invaluable to investigators in nearly all areas of biomedical research. The use of genetically engineered mice has allowed researchers to explore fundamental functions of genes in a mammal that shares substantial similarities with human physiology and pathology. Genetically engineered mice are often used as animal models of human diseases that are vital tools in investigating disease development and in developing and testing novel therapies. Gene targeting in embryonic stem cells allows endogenous genes to be specifically altered. As knowledge regarding precise genetic abnormalities underlying a variety of dermatological conditions continues to emerge, the ability to introduce corresponding alterations in endogenous gene loci in mice, often at a single base pair level, has become essential for detailed studies of these genetic diseases. In this review, we provide examples of mouse models harboring modified endogenous gene(s), generated using the technique commonly referred to as the "knock-in" approach, to exemplify the important and sometimes superior role of this methodology in dermatological research.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.