ArticleInsect biochemistry and molecular biology2008
Extensive gene amplification and concerted evolution within the CPR family of cuticular proteins in mosquitoes.
Article in Insect biochemistry and molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Global Gene Expression Analysis Reveals Complex Cuticle Organization of the Tribolium Compound Eye.Genome biology and evolution · 2023Article
- A globalBMC bioinformatics · 2022Article
- Cuticular Structure Proteomics in the Pea AphidJournal of proteome research · 2020Article
- Proteomics reveals localization of cuticular proteins in Anopheles gambiae.Insect biochemistry and molecular biology · 2019Article
- Localization of RR-1 and RR-2 cuticular proteins within the cuticle of Anopheles gambiae.Arthropod structure & development · 2017Article
- Properties of the cuticular proteins of Anopheles gambiae as revealed by serial extraction of adults.PloS one · 2017Article
- Immunolocalization of cuticular proteins in Johnston's organ and the corneal lens of Anopheles gambiae.Arthropod structure & development · 2016Article
- Distribution of cuticular proteins in different structures of adult Anopheles gambiae.Insect biochemistry and molecular biology · 2016Article
- Analysis of chitin-binding proteins from Manduca sexta provides new insights into evolution of peritrophin A-type chitin-binding domains in insects.Insect biochemistry and molecular biology · 2015Article
- Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.Science (New York, N.Y.) · 2015Article
- Changes in transcript abundance for cuticular proteins and other genes three hours after a blood meal in Anopheles gambiae.Insect biochemistry and molecular biology · 2014Article
- Gene duplication as a mechanism of genomic adaptation to a changing environment.Proceedings. Biological sciences · 2012Review
- Article
- Structural cuticular proteins from arthropods: annotation, nomenclature, and sequence characteristics in the genomics era.Insect biochemistry and molecular biology · 2010Review
- Annotation and analysis of low-complexity protein families of Anopheles gambiae that are associated with cuticle.Insect molecular biology · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Annotation of the Anopheles gambiae genome has revealed a large increase in the number of genes encoding cuticular proteins with the Rebers and Riddiford Consensus (the CPR gene family) relative to Drosophila melanogaster. This increase reflects an expansion of the RR-2 group of CPR genes, particularly the amplification of sets of highly similar paralogs. Patterns of nucleotide variation indicate that extensive concerted evolution is occurring within these clusters. The pattern of concerted evolution is complex, however, as sequence similarity within clusters is uncorrelated with gene order and orientation, and no comparable clusters occur within similarly compact arrays of the RR-1 group in mosquitoes or in either group in D. melanogaster. The dearth of pseudogenes suggests that sequence clusters are maintained by selection for high gene-copy number, perhaps due to selection for high expression rates. This hypothesis is consistent with the apparently parallel evolution of compact gene architectures within sequence clusters relative to single-copy genes. We show that RR-2 proteins from sequence-cluster genes have complex repeats and extreme amino-acid compositions relative to single-copy CPR proteins in An. gambiae, and that the amino-acid composition of the N-terminal and C-terminal sequence flanking the chitin-binding consensus region evolves in a correlated fashion.
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