ArticleBMC evolutionary biology2008
Evolution of the CDKN1C-KCNQ1 imprinted domain.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Molecular Basis of Beckwith-Wiedemann Syndrome Spectrum with Associated Tumors and Consequences for Clinical Practice.Cancers · 2022Review
- The Role of Long Non-coding RNAs in Human Imprinting Disorders: Prospective Therapeutic Targets.Frontiers in cell and developmental biology · 2021Review
- Dysregulated Gene Expression of Imprinted and X-Linked Genes: A Link to Poor Development of Bovine Haploid Androgenetic Embryos.Frontiers in cell and developmental biology · 2021Article
- Territorial Behavior and Social Stability in the Mouse Require Correct Expression of ImprintedFrontiers in behavioral neuroscience · 2018Article
- Genomic imprinting does not reduce the dosage of UBE3A in neurons.Epigenetics & chromatin · 2017Article
- Review
- Characterization, tissue expression, and imprinting analysis of the porcine CDKN1C and NAP1L4 genes.Journal of biomedicine & biotechnology · 2012Article
- Depletion of Kcnq1ot1 non-coding RNA does not affect imprinting maintenance in stem cells.Development (Cambridge, England) · 2011Article
- Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting.BMC evolutionary biology · 2011Article
- The evolution of mammalian genomic imprinting was accompanied by the acquisition of novel CpG islands.Genome biology and evolution · 2011Article
- The imprinted Phlda2 gene regulates extraembryonic energy stores.Molecular and cellular biology · 2010Article
- The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.Human molecular genetics · 2009Article
- Placentation in Marsupials.Advances in anatomy, embryology, and cell biologyArticle
- Imprinting evolution and human health.Mammalian genome : official journal of the International Mammalian Genome SocietyReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenomic imprinting occurs in both marsupial and eutherian mammals. The CDKN1C and IGF2 genes are both imprinted and syntenic in the mouse and human, but in marsupials only IGF2 is imprinted. This study examines the evolution of features that, in eutherians, regulate CDKN1C imprinting.
resultsDespite the absence of imprinting, CDKN1C protein was present in the tammar wallaby placenta. Genomic analysis of the tammar region confirmed that CDKN1C is syntenic with IGF2. However, there are fewer LTR and DNA elements in the region and in intron 9 of KCNQ1. In addition there are fewer LINEs in the tammar compared with human and mouse. While the CpG island in intron 10 of KCNQ1 and promoter elements could not be detected, the antisense transcript KCNQ1OT1 that regulates CDKN1C imprinting in human and mouse is still expressed.
conclusionCDKN1C has a conserved function, likely antagonistic to IGF2, in the mammalian placenta that preceded its acquisition of imprinting. CDKN1C resides in synteny with IGF2, demonstrating that imprinting of the two genes did not occur concurrently to balance maternal and paternal influences on the growth of the placenta. The expression of KCNQ1OT1 in the absence of CDKN1C imprinting suggests that antisense transcription at this locus preceded imprinting of this domain. These findings demonstrate the stepwise accumulation of control mechanisms within imprinted domains and show that CDKN1C imprinting cannot be due to its synteny with IGF2 or with its placental expression in mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.