ReviewJournal of anatomy2008
Synthetic morphology: prospects for engineered, self-constructing anatomies.
Review in Journal of anatomy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 95 citations in OpenAlex.
- Engineering Basal Cognition: Minimal Genetic Circuits for Habituation, Sensitization, and Massed-Spaced Learning.ACS synthetic biology · 2026Article
- Open problems in synthetic multicellularity.NPJ systems biology and applications · 2024Article
- Programming the elongation of mammalian cell aggregates with synthetic gene circuits.bioRxiv : the preprint server for biology · 2024Article
- Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- A synthetic population-level oscillator in non-microfluidic environments.Communications biology · 2023Article
- Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues.Nature communications · 2022Article
- Ecological firewalls for synthetic biology.iScience · 2022Article
- Synthetic Morphogenesis: introducing IEEE journal readers to programming living mammalian cells to make structures.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2022Article
- Synthetic living machines: A new window on life.iScience · 2021Review
- Synthetic biology in various cellular and molecular fields: applications, limitations, and perspective.Molecular biology reports · 2020Review
- Engineering pattern formation and morphogenesis.Biochemical Society transactions · 2020Review
- Synthetic Morphology: A Vision of Engineering Biological Form.Journal of the history of biology · 2020Article
- Synthetic development: building mammalian multicellular structures with artificial genetic programs.Current opinion in biotechnology · 2019Review
- Intercellular adhesion promotes clonal mixing in growing bacterial populations.Journal of the Royal Society, Interface · 2018Article
- SynPharm: A Guide to PHARMACOLOGY Database Tool for Designing Drug Control into Engineered Proteins.ACS omega · 2018Article
- Programming self-organizing multicellular structures with synthetic cell-cell signaling.Science (New York, N.Y.) · 2018Article
- Article
- Guided morphogenesis through optogenetic activation of Rho signalling during early Drosophila embryogenesis.Nature communications · 2018Article
- Calcium as a signal integrator in developing epithelial tissues.Physical biology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper outlines prospects for applying the emerging techniques of synthetic biology to the field of anatomy, with the aim of programming cells to organize themselves into specific, novel arrangements, structures and tissues. There are two main reasons why developing this hybrid discipline--synthetic morphology--would be useful. The first is that having a way to engineer self-constructing assemblies of cells would provide a powerful means of tissue engineering for clinical use in surgery and regenerative medicine. The second is that construction of simple novel systems according to theories of morphogenesis gained from study of real embryos will provide a means of testing those theories rigorously, something that is very difficult to do by manipulation of complex embryos. This paper sets out the engineering requirements for synthetic morphology, which include the development of a library of sensor modules, regulatory modules and effector modules that can be connected functionally within cells. A substantial number of sensor and regulatory modules already exist and this paper argues that some potential effector modules have already been identified. The necessary library may therefore be within reach. The paper ends by suggesting a set of challenges, ranging from simple to complex, the achievement of which would provide valuable proofs of concept.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.