ArticlePloS one2008
The binary protein interactome of Treponema pallidum--the syphilis spirochete.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- The protein interactome of the citrus Huanglongbing pathogen Candidatus Liberibacter asiaticus.Nature communications · 2023Article
- Computational Network Inference for Bacterial Interactomics.mSystems · 2022Review
- Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar.PLoS neglected tropical diseases · 2021Article
- Computationally Reconstructed Interactome ofInternational journal of molecular sciences · 2021Article
- The tapeworm interactome: inferring confidence scored protein-protein interactions from the proteome of Hymenolepis microstoma.BMC genomics · 2020Article
- Proteome Data Improves Protein Function Prediction in the Interactome ofMolecular & cellular proteomics : MCP · 2018Article
- Protein-protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics.Beilstein journal of organic chemistry · 2018Review
- Making the Right Choice: Critical Parameters of the Y2H Systems.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Review
- Bacterial protein meta-interactomes predict cross-species interactions and protein function.BMC bioinformatics · 2017Article
- Structural basis for the CsrA-dependent modulation of translation initiation by an ancient regulatory protein.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Reconstruction and Application of Protein-Protein Interaction Network.International journal of molecular sciences · 2016Review
- Quantitative Tagless Copurification: A Method to Validate and Identify Protein-Protein Interactions.Molecular & cellular proteomics : MCP · 2016Article
- Computational analysis of protein interaction networks for infectious diseases.Briefings in bioinformatics · 2016Review
- Bacterial Interactomes: Interacting Protein Partners Share Similar Function and Are Validated in Independent Assays More Frequently Than Previously Reported.Molecular & cellular proteomics : MCP · 2016Article
- The interactome of Streptococcus pneumoniae and its bacteriophages show highly specific patterns of interactions among bacteria and their phages.Scientific reports · 2016Article
- Prediction and characterization of protein-protein interaction network in Bacillus licheniformis WX-02.Scientific reports · 2016Article
- Quantifying noise in mass spectrometry and yeast two-hybrid protein interaction detection experiments.Journal of the Royal Society, Interface · 2015Article
- Bacterial protein networks: properties and functions.Nature reviews. Microbiology · 2015Review
- Mapping the Protein-Protein Interactome Networks Using Yeast Two-Hybrid Screens.Advances in experimental medicine and biology · 2015Review
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Authors and funding
7 authors.
Funding
Abstract
Protein interaction networks shed light on the global organization of proteomes but can also place individual proteins into a functional context. If we know the function of bacterial proteins we will be able to understand how these species have adapted to diverse environments including many extreme habitats. Here we present the protein interaction network for the syphilis spirochete Treponema pallidum which encodes 1,039 proteins, 726 (or 70%) of which interact via 3,649 interactions as revealed by systematic yeast two-hybrid screens. A high-confidence subset of 991 interactions links 576 proteins. To derive further biological insights from our data, we constructed an integrated network of proteins involved in DNA metabolism. Combining our data with additional evidences, we provide improved annotations for at least 18 proteins (including TP0004, TP0050, and TP0183 which are suggested to be involved in DNA metabolism). We estimate that this "minimal" bacterium contains on the order of 3,000 protein interactions. Profiles of functional interconnections indicate that bacterial proteins interact more promiscuously than eukaryotic proteins, reflecting the non-compartmentalized structure of the bacterial cell. Using our high-confidence interactions, we also predict 417,329 homologous interactions ("interologs") for 372 completely sequenced genomes and provide evidence that at least one third of them can be experimentally confirmed.
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