ArticlePLoS neglected tropical diseases2008
High levels of genetic differentiation between Ugandan Glossina fuscipes fuscipes populations separated by Lake Kyoga.
Article in PLoS neglected tropical diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Systematic review and meta-analysis of the spatio-temporal changes in apparent tsetse fly density in Uganda from 1980 to 2022.Research square · 2025Article
- Prospects for application of population genetics for control of tsetse flies in Africa.Current opinion in insect science · 2025Review
- Development and characterization of microsatellite markers for the tsetse species Glossina brevipalpis and preliminary population genetics analyses.Parasite (Paris, France) · 2023Article
- Spatial analysis of G.f.fuscipes abundance in Uganda using Poisson and Zero-Inflated Poisson regression models.PLoS neglected tropical diseases · 2021Article
- Population Structure and Migration Patterns of the Tsetse Fly Glossina fuscipes in Congo-Brazzaville.The American journal of tropical medicine and hygiene · 2020Article
- The population genomics of multiple tsetse fly (Glossina fuscipes fuscipes) admixture zones in Uganda.Molecular ecology · 2019Article
- Diversity and phylogenetic relationships of Glossina populations in Nigeria and the Cameroonian border region.BMC microbiology · 2018Article
- A spatial genetics approach to inform vector control of tsetse flies (Ecology and evolution · 2018Article
- Temporal genetic differentiation in Glossina pallidipes tsetse fly populations in Kenya.Parasites & vectors · 2017Article
- Genetic diversity and population structure of the tsetse fly Glossina fuscipes fuscipes (Diptera: Glossinidae) in Northern Uganda: Implications for vector control.PLoS neglected tropical diseases · 2017Article
- Evidence of temporal stability in allelic and mitochondrial haplotype diversity in populations of Glossina fuscipes fuscipes (Diptera: Glossinidae) in northern Uganda.Parasites & vectors · 2016Article
- Mitochondrial DNA sequence divergence and diversity of Glossina fuscipes fuscipes in the Lake Victoria basin of Uganda: implications for control.Parasites & vectors · 2015Article
- Genetic diversity and population structure of Trypanosoma brucei in Uganda: implications for the epidemiology of sleeping sickness and Nagana.PLoS neglected tropical diseases · 2015Article
- Analysis of multiple tsetse fly populations in Uganda reveals limited diversity and species-specific gut microbiota.Applied and environmental microbiology · 2014Article
- Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda.Trends in parasitology · 2013Review
- Wolbachia association with the tsetse fly, Glossina fuscipes fuscipes, reveals high levels of genetic diversity and complex evolutionary dynamics.BMC evolutionary biology · 2013Article
- Genetically distinct Glossina fuscipes fuscipes populations in the Lake Kyoga region of Uganda and its relevance for human African trypanosomiasis.BioMed research international · 2013Article
- The population structure of Glossina fuscipes fuscipes in the Lake Victoria basin in Uganda: implications for vector control.Parasites & vectors · 2012Article
- Implications of microfauna-host interactions for trypanosome transmission dynamics in Glossina fuscipes fuscipes in Uganda.Applied and environmental microbiology · 2012Article
- Influence of host phylogeographic patterns and incomplete lineage sorting on within-species genetic variability in Wigglesworthia species, obligate symbionts of tsetse flies.Applied and environmental microbiology · 2011Article
Corrections and comments
- Erratum issuedLokedi, Loyce M [corrected to Okedi, Loyce M A]
Authors and funding
11 authors.
Funding
Abstract
backgroundGlossina fuscipes fuscipes is the major vector of human African trypanosomiasis, commonly referred to as sleeping sickness, in Uganda. In western and eastern Africa, the disease has distinct clinical manifestations and is caused by two different parasites: Trypanosoma brucei rhodesiense and T. b. gambiense. Uganda is exceptional in that it harbors both parasites, which are separated by a narrow 160-km belt. This separation is puzzling considering there are no restrictions on the movement of people and animals across this region. METHODOLOGY AND
resultsWe investigated whether genetic heterogeneity of G. f. fuscipes vector populations can provide an explanation for this disjunct distribution of the Trypanosoma parasites. Therefore, we examined genetic structuring of G. f. fuscipes populations across Uganda using newly developed microsatellite markers, as well as mtDNA. Our data show that G. f. fuscipes populations are highly structured, with two clearly defined clusters that are separated by Lake Kyoga, located in central Uganda. Interestingly, we did not find a correlation between genetic heterogeneity and the type of Trypanosoma parasite transmitted.
conclusionsThe lack of a correlation between genetic structuring of G. f. fuscipes populations and the distribution of T. b. gambiense and T. b. rhodesiense indicates that it is unlikely that genetic heterogeneity of G. f. fuscipes populations explains the disjunct distribution of the parasites. These results have important epidemiological implications, suggesting that a fusion of the two disease distributions is unlikely to be prevented by an incompatibility between vector populations and parasite.
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