ArticlePloS one2008
Duplicated paralogous genes subject to positive selection in the genome of Trypanosoma brucei.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Computer-Aided Multi-Epitope Vaccine Design againstInternational journal of environmental research and public health · 2022Article
- Large Scale Analyses and Visualization of Adaptive Amino Acid Changes Projects.Interdisciplinary sciences, computational life sciences · 2018Article
- Antagonistic Coevolution of MER Tyrosine Kinase Expression and Function.Molecular biology and evolution · 2017Article
- Gene Duplication Analysis Reveals No Ancient Whole Genome Duplication but Extensive Small-Scale Duplications during Genome Evolution and Adaptation ofFrontiers in cellular and infection microbiology · 2017Article
- POTION: an end-to-end pipeline for positive Darwinian selection detection in genome-scale data through phylogenetic comparison of protein-coding genes.BMC genomics · 2015Article
- Deep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients.PLoS neglected tropical diseases · 2015Article
- The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!Frontiers in pharmacology · 2015Review
- Insect stage-specific adenylate cyclases regulate social motility in African trypanosomes.Eukaryotic cell · 2015Article
- Natural selection on coding and noncoding DNA sequences is associated with virulence genes in a plant pathogenic fungus.Genome biology and evolution · 2014Article
- Insect stage-specific receptor adenylate cyclases are localized to distinct subdomains of the Trypanosoma brucei Flagellar membrane.Eukaryotic cell · 2014Article
- Evolution of PAS domains and PAS-containing genes in eukaryotes.Chromosoma · 2014Article
- Pathogen evolution and the immunological niche.Annals of the New York Academy of Sciences · 2014Article
- Extensive local gene duplication and functional divergence among paralogs in Atlantic salmon.Genome biology and evolution · 2014Article
- Regulation of Schistosoma mansoni development and reproduction by the mitogen-activated protein kinase signaling pathway.PLoS neglected tropical diseases · 2014Article
- A survey of innovation through duplication in the reduced genomes of twelve parasites.PloS one · 2014Article
- Article
- Patterns of evolution at the gametophytic self-incompatibility Sorbus aucuparia (Pyrinae) S pollen genes support the non-self recognition by multiple factors model.Journal of experimental botany · 2013Article
- Comparative genomics of parasitic silkworm microsporidia reveal an association between genome expansion and host adaptation.BMC genomics · 2013Article
- The Schistosoma mansoni phylome: using evolutionary genomics to gain insight into a parasite's biology.BMC genomics · 2012Article
- Evidence for maintenance of sex determinants but not of sexual stages in red yeasts, a group of early diverged basidiomycetes.BMC evolutionary biology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWhole genome studies have highlighted duplicated genes as important substrates for adaptive evolution. We have investigated adaptive evolution in this class of genes in the human parasite Trypanosoma brucei, as indicated by the ratio of non-synonymous (amino-acid changing) to synonymous (amino acid retaining) nucleotide substitution rates. METHODOLOGY/PRINCIPAL
findingsWe have identified duplicated genes that are most rapidly evolving in this important human parasite. This is the first attempt to investigate adaptive evolution in this species at the codon level. We identify 109 genes within 23 clusters of paralogous gene expansions to be subject to positive selection. CONCLUSIONS/SIGNIFICANCE: Genes identified include surface antigens in both the mammalian and insect host life cycle stage suggesting that competitive interaction is not solely with the adaptive immune system of the mammalian host. Also surface transporters related to drug resistance and genes related to developmental progression are detected. We discuss how adaptive evolution of these genes may highlight lineage specific processes essential for parasite survival. We also discuss the implications of adaptive evolution of these targets for parasite biology and control.
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