ReviewJournal of human hypertension2008
Macro and microvasculature in hypertension: therapeutic aspects.
Review in Journal of human hypertension, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Critical Closing Pressure and Cerebrovascular Resistance Responses to Intracranial Pressure Variations in Neurocritical Patients.Neurocritical care · 2023Article
- A high normal ankle-brachial index is associated with biopsy-proven severe renal small artery intimal thickening and impaired renal function in chronic kidney disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Observational
- Vascular Aging and Central Aortic Blood Pressure: From Pathophysiology to Treatment.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020Review
- Vascular Aging and Disease of the Small Vessels.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019Review
- Comparison of lercanidipine plus hydrochlorothiazide vs. lercanidipine plus enalapril on micro and macrocirculation in patients with mild essential hypertension.Internal and emergency medicine · 2017Article
- Relationships between blood pressure variability and indices of large artery stiffness: does the microvasculature play a role?Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Relationship Between Carotid Atherosclerosis and Pulse Pressure with Renal Hemodynamics in Hypertensive Patients.American journal of hypertension · 2016Article
- Interactions between macro- and micro-circulation: are they relevant?High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2015Review
- Predictive role of renal resistive index for clinical outcome after revascularization in hypertensive patients with atherosclerotic renal artery stenosis: a monocentric observational study.Cardiovascular ultrasound · 2014Observational
- Role of T lymphocytes in angiotensin II-mediated microvascular thrombosis.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Arterial aging--hemodynamic changes and therapeutic options.Nature reviews. Cardiology · 2010Review
- Aortic distensibility associates with increased ascending thoracic aorta diameter and left ventricular diastolic dysfunction in patients with coronary artery ectasia.Heart and vessels · 2010Article
- De-stiffening drug therapy and blood pressure control.Integrated blood pressure control · 2010Article
- Arterial stiffness, hypertension, and rational use of nebivolol.Vascular health and risk management · 2009Review
- Targeting the arterial wall, but what is the target?Journal of human hypertension · 2009Article
- Skin microcirculation and hypertension: is there a connection?Jornal brasileiro de nefrologiaReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrovasculature, microvasculature and the heart determine the structure and function of the circulatory system. Due to the viscoelastic properties of large arteries, the pulsatile pressure and flow that result from intermittent ventricular ejection is smoothed out, so that microvasculature mediates the delivery of nutrients and oxygen to tissues steadily. The disruption of this function, which occurs when microvascular structure develops in response to hypertension, leads to end-organ damage. Microvascular structure is not only the site of vascular resistance, but also the origin of most of the wave reflections generating increased central systolic blood pressure (SBP) in the elderly. Nowadays many data of the literature suggest that hypertension-related damage to the micro and macrovascular system may be manageable through pharmacological agents. Among them, beta-blocking agents and diuretics poorly modify microvascular structure, whereas angiotensin and calcium entry blockade has an opposite effect, thereby reducing central wave reflections and, finally, causing a selective SBP reduction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.