ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2008
Intermediate filament protein synemin contributes to the migratory properties of astrocytoma cells by influencing the dynamics of the actin cytoskeleton.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- SRC and ERK Regulate the Turnover of Cytoskeletal Keratin Filaments.International journal of molecular sciences · 2025Article
- Regulation of microtubule nucleation in glioblastoma cells by ARF GTPase-activating proteins GIT1 and GIT2 and protein kinase C.Cancer cell international · 2025Article
- Nestin is a New Partner in Endothelial Colony Forming Cell Angiogenic Potential.Stem cell reviews and reports · 2023Article
- Synemin promotes pulmonary artery smooth muscle cell phenotypic switch in shunt-induced pulmonary arterial hypertension.ESC heart failure · 2022Article
- Review
- Determination of distinctive hypomethylated genes in African American colorectal neoplastic lesions.Therapeutic advances in gastroenterology · 2020Article
- Mitigating temozolomide resistance in glioblastoma via DNA damage-repair inhibition.Journal of the Royal Society, Interface · 2020Article
- Synemin Redefined: Multiple Binding Partners Results in Multifunctionality.Frontiers in cell and developmental biology · 2020Review
- The Cytoskeleton-A Complex Interacting Meshwork.Cells · 2019Review
- A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy.Oncotarget · 2015Article
- Synemin: an evolving role in tumor growth and progression.Journal of cachexia, sarcopenia and muscle · 2014Article
- Movers and shakers: cell cytoskeleton in cancer metastasis.British journal of pharmacology · 2014Review
- Review on intermediate filaments of the nervous system and their pathological alterations.Histochemistry and cell biology · 2013Review
- Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A.Molecular biology of the cell · 2012Article
- Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia.The Journal of cell biology · 2011Review
- Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation.Journal of neuropathology and experimental neurology · 2011Article
- Nestin is a novel target for suppressing pancreatic cancer cell migration, invasion and metastasis.Cancer biology & therapy · 2011Article
- Expression profiles of nestin and synemin in reactive astrocytes and Müller cells following retinal injury: a comparison with glial fibrillar acidic protein and vimentin.Molecular vision · 2010Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We have shown previously that, in astrocytoma cells, synemin is present at the leading edge, an unusual localization for an intermediate filament (IF) protein. Here, we report that synemin down-regulation with specific small hairpin RNAs (shRNAs) sharply decreased the migration of astrocytoma cells. The presence of synemin at the leading edge also correlated with a high migratory potential, as shown by comparing astrocytoma cells to carcinoma cells without synemin at the leading edge. Synemin-silenced astrocytoma cells were smaller and spread more slowly than controls. In addition, synemin silencing reduced proliferation without increasing apoptosis. The adhesion to substratum and distribution of vinculin in focal contacts of synemin-silenced astrocytoma cells were similar to those of controls. Synemin-silenced cells, however, exhibited a reduction in the amount of filamentous (F) -actin and of alpha-actinin, but not of vinculin, associated with F-actin. Altogether, these results demonstrate that synemin is important for the malignant behavior of astrocytoma cells and that it contributes to the high motility of these cells by modulating the dynamics of alpha-actinin and actin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.