ArticleJournal of neurophysiology2008
Trunk sensorimotor cortex is essential for autonomous weight-supported locomotion in adult rats spinalized as P1/P2 neonates.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Rehabilitation Training after Spinal Cord Injury Affects Brain Structure and Function: From Mechanisms to Methods.Biomedicines · 2023Review
- Hindlimb Somatosensory Information Influences Trunk Sensory and Motor Cortices to Support Trunk Stabilization.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Ipsilesional Motor Cortex Plasticity Participates in Spontaneous Hindlimb Recovery after Lateral Hemisection of the Thoracic Spinal Cord in the Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Serotonin receptor and dendritic plasticity in the spinal cord mediated by chronic serotonergic pharmacotherapy combined with exercise following complete SCI in the adult rat.Experimental neurology · 2018Article
- Cortex-dependent recovery of unassisted hindlimb locomotion after complete spinal cord injury in adult rats.eLife · 2017Article
- Teaching Adult Rats Spinalized as Neonates to Walk Using Trunk Robotic Rehabilitation: Elements of Success, Failure, and Dependence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Trunk robot rehabilitation training with active stepping reorganizes and enriches trunk motor cortex representations in spinal transected rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Cortical reorganization after spinal cord injury: always for good?Neuroscience · 2014Review
- Plasticity and alterations of trunk motor cortex following spinal cord injury and non-stepping robot and treadmill training.Experimental neurology · 2014Article
- Adaptive changes in the motor cortex during and after longterm forelimb immobilization in adult rats.The Journal of physiology · 2014Article
- Use of quadrupedal step training to re-engage spinal interneuronal networks and improve locomotor function after spinal cord injury.Brain : a journal of neurology · 2013Article
- Robotic loading during treadmill training enhances locomotor recovery in rats spinally transected as neonates.Journal of neurophysiology · 2013Article
- Serotonergic pharmacotherapy promotes cortical reorganization after spinal cord injury.Experimental neurology · 2013Article
- Adaptation to a cortex-controlled robot attached at the pelvis and engaged during locomotion in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Robot-driven spinal epidural stimulation compared with conventional stimulation in adult spinalized rats.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2011Article
- How spinalized rats can walk: biomechanics, cortex, and hindlimb muscle scaling--implications for rehabilitation.Annals of the New York Academy of Sciences · 2010Article
- Spinal cord modularity: evolution, development, and optimization and the possible relevance to low back pain in man.Experimental brain research · 2010Review
- Multiple types of movement-related information encoded in hindlimb/trunk cortex in rats and potentially available for brain-machine interface controls.IEEE transactions on bio-medical engineering · 2009Article
- Functional and anatomical reorganization of the sensory-motor cortex after incomplete spinal cord injury in adult rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Unlike adult spinalized rats, approximately 20% of rats spinalized as postnatal day 1 or 2 (P1/P2) neonates achieve autonomous hindlimb weight support. Cortical representations of mid/low trunk occur only in such rats with high weight support. However, the importance of hindlimb/trunk motor cortex in function of spinalized rats remains unclear. We tested the importance of trunk sensorimotor cortex in their locomotion using lesions guided by cortical microstimulation in P1/P2 weight-supporting neonatal spinalized rats and controls. In four intact control rats, lesions of hindlimb/trunk cortex caused no treadmill deficits. All spinalized rats lesioned in trunk cortex (n = 16: 4 transplant, 6 transect, 6 transect + fibrin glue) lost an average of about 40% of their weight support. Intact trunk cortex was essential to their level of function. Lesion of trunk cortex substantially increased roll of the hindquarters, which correlated to diminished weight support, but other kinematic stepping parameters showed little change. Embryonic day 14 (E14) transplants support development of the trunk motor representations in their normal location. We tested the role of novel relay circuits arising from the grafts in such cortical representations in E14 transplants using the rats that received (noncellular) fibrin glue grafting at P1/P2 (8 allografts and 32 xenografts). Fibrin-repaired rats with autonomous weight support also had trunk cortical representations similar to those of E14 transplant rats. Thus acellular repair and intrinsic plasticity were sufficient to support the observed features. Our data show that effective cortical mechanisms for trunk control are essential for autonomous weight support in P1/P2 spinalized rats and these can be achieved by intrinsic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.