ArticleAmerican journal of physiology. Cell physiology2008
Force deficits and breakage rates after single lengthening contractions of single fast fibers from unconditioned and conditioned muscles of young and old rats.
Article in American journal of physiology. Cell physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- CORP: In vivo muscle strength-perspectives on the design and interpretation of preclinical animal studies.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Review
- Long Noncoding RNA lncRNA-3 Recruits PRC2 for MyoD1 Silencing to Suppress Muscle Regeneration During Aging.International journal of molecular sciences · 2024Article
- History-dependent muscle resistance to stretch remains high after small, posturally relevant pre-movements.The Journal of experimental biology · 2023Article
- Age-Related Susceptibility to Muscle Damage Following Mechanotherapy in Rats Recovering From Disuse Atrophy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- The influence of capillarization on satellite cell pool expansion and activation following exercise-induced muscle damage in healthy young men.The Journal of physiology · 2018Article
- Combination of Coenzyme QOxidative medicine and cellular longevity · 2018Article
- Age-related functional changes and susceptibility to eccentric contraction-induced damage in skeletal muscle cell.Integrative medicine research · 2016Review
- Increased Adipocyte Area in Injured Muscle With Aging and Impaired Remodeling in Female Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Measurement of Maximum Isometric Force Generated by Permeabilized Skeletal Muscle Fibers.Journal of visualized experiments : JoVE · 2015Article
- Efflux of creatine kinase from isolated soleus muscle depends on age, sex and type of exercise in mice.Journal of sports science & medicine · 2015Article
- Differential susceptibility on myosin heavy chain isoform following eccentric-induced muscle damage.Journal of exercise rehabilitation · 2014Review
- Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength.Aging cell · 2012Article
- Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults.Age (Dordrecht, Netherlands) · 2012Article
- The regulation and function of the striated muscle activator of rho signaling (STARS) protein.Frontiers in physiology · 2012Article
- Age- and gender-related changes in contractile properties of non-atrophied EDL muscle.PloS one · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The deficit in force generation is a measure of the magnitude of damage to sarcomeres caused by lengthening contractions of either single fibers or whole muscles. In addition, permeabilized single fibers may suffer breakages. Our goal was to understand the interaction between breakages and force deficits in "young" and "old" permeabilized single fibers from control muscles of young and old rats and "conditioned" fibers from muscles that completed a 6-wk program of in vivo lengthening contractions. Following single lengthening contractions of old-control fibers compared with young-control fibers, the twofold greater force deficits at a 10% strain support the concept of an age-related increase in the susceptibility of fibers to mechanical damage. In addition, the much higher breakage rates for old fibers at all strains tested indicate an increase with aging in the number of fibers at risk of being severely injured during any given stretch. Following the 6-wk program of lengthening contractions, young-conditioned fibers and old-conditioned fibers were not different with respect to force deficit or the frequency of breakages. A potential mechanism for the increased resistance to stretch-induced damage of old-conditioned fibers is that, through intracellular damage and subsequent degeneration and regeneration, weaker sarcomeres were replaced by stronger sarcomeres. These data indicate that, despite the association of high fiber breakage rates and large force deficits with aging, the detrimental characteristics of old fibers were improved by a conditioning program that altered both sarcomeric characteristics as well as the overall structural integrity of the fibers.
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