ArticleThe European respiratory journal2008
Angiotensinogen gene G-6A polymorphism influences idiopathic pulmonary fibrosis disease progression.
Article in The European respiratory journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Genetic Polymorphism in Angiotensinogen and Its Association with Cardiometabolic Diseases.Metabolites · 2022Review
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- Proteomic analysis of serum samples of paracoccidioidomycosis patients with severe pulmonary sequel.PLoS neglected tropical diseases · 2021Article
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- Review
- Towards a global initiative for fibrosis treatment (GIFT).ERJ open research · 2017Article
- Profibrosing effect of angiotensin converting enzyme inhibitors in human lung fibroblasts.Lung · 2015Article
- Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis via modulating angiotensin-converting enzyme 2/ angiotensin-(1-7) axis in rats.International journal of medical sciences · 2014Article
- Genetic architecture of human fibrotic diseases: disease risk and disease progression.Frontiers in pharmacology · 2013Review
- Article
- Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis.Biochimica et biophysica acta · 2013Article
- Angiotensinogen gene transcription in pulmonary fibrosis.International journal of peptides · 2012Article
- Article
- The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension.American journal of respiratory and critical care medicine · 2010Article
- Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression.BMC pulmonary medicine · 2010Article
- Polymorphisms in thrombophilia and renin-angiotensin system pathways, preterm delivery, and evidence of placental hemorrhage.American journal of obstetrics and gynecology · 2009Article
- JunD and HIF-1alpha mediate transcriptional activation of angiotensinogen by TGF-beta1 in human lung fibroblasts.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
Angiotensin II is a growth factor that plays a key role in the physiopathology of idiopathic pulmonary fibrosis (IPF). A nucleotide substitution of an adenine instead of a guanine (G-6A) in the proximal promoter region of angiotensinogen (AGT), the precursor of angiotensin II, has been associated with an increased gene transcription rate. In order to investigate whether the G-6A polymorphism of the AGT gene is associated with IPF development, severity and progression, the present study utilised a case-control study design and genotyped G-6A in 219 patients with IPF and 224 control subjects. The distribution of G-6A genotypes and alleles did not significantly differ between cases and controls. The G-6A polymorphism of the AGT gene was not associated with disease severity at diagnosis. The presence of the A allele was strongly associated with increased alveolar arterial oxygen tension difference during follow-up, after controlling for the confounding factors. Higher alveolar arterial oxygen tension changes over time were observed in patients with the AA genotype (0.37+/-0.7 mmHg (0.049+/-0.093 kPa) per month) compared to GA genotype (0.12+/-1 mmHg (0.016+/-0.133 kPa) per month) and GG genotype (0.2+/-0.6 mmHg (0.027+/-0.080 kPa) per month). G-6A polymorphism of the angiotensinogen gene is associated with idiopathic pulmonary fibrosis progression but not with disease predisposition. This polymorphism could have a predictive significance in idiopathic pulmonary fibrosis patients.
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