ArticleNucleic acids research2008
ENDEAVOUR update: a web resource for gene prioritization in multiple species.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.
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Who cites it
96 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic prioritization and integrative analysis of copy number variations in schizophrenia reveal key schizophrenia susceptibility genes.Schizophrenia bulletin · 2014Pooled it
- Exome sequencing to explore the possibility of predicting genetic susceptibility to the joint occurrence of polycystic ovary syndrome and Hashimoto's thyroiditis.Frontiers in immunology · 2023Article
- Identification of the novel FOXP3-dependent TFrontiers in immunology · 2023Article
- Disease gene prediction with privileged information and heteroscedastic dropout.Bioinformatics (Oxford, England) · 2021Article
- Biological Network Mining.Methods in molecular biology (Clifton, N.J.) · 2021Article
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- A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases.Journal of integrative bioinformatics · 2019Review
- BEERE: a web server for biomedical entity expansion, ranking and explorations.Nucleic acids research · 2019Article
- eDiVA-Classification and prioritization of pathogenic variants for clinical diagnostics.Human mutation · 2019Article
- Gene prioritization using Bayesian matrix factorization with genomic and phenotypic side information.Bioinformatics (Oxford, England) · 2018Article
- MGOGP: a gene module-based heuristic algorithm for cancer-related gene prioritization.BMC bioinformatics · 2018Article
- Characterization of a new B-ALL cell line with constitutional defect of the Notch signaling pathway.Oncotarget · 2018Article
- Identification and Analysis of Rice Yield-Related Candidate Genes by Walking on the Functional Network.Frontiers in plant science · 2018Article
- A Strategy for Identifying Quantitative Trait Genes Using Gene Expression Analysis and Causal Analysis.Genes · 2017Review
- Dysfunction of Myosin Light-Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically-Engineered Rats.Journal of the American Heart Association · 2017Article
- DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways.Neoplasia (New York, N.Y.) · 2017Article
- A large-scale benchmark of gene prioritization methods.Scientific reports · 2017Article
- Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.Oncotarget · 2017Article
- Clinical Applicability of Whole-Exome Sequencing Exemplified by a Study in Young Adults with the Advanced Cryptogenic Cholestatic Liver Diseases.Gastroenterology research and practice · 2017Article
- Whole-genome sequencing suggests mechanisms for 22q11.2 deletion-associated Parkinson's disease.PloS one · 2017Article
36 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endeavour (http://www.esat.kuleuven.be/endeavourweb; this web site is free and open to all users and there is no login requirement) is a web resource for the prioritization of candidate genes. Using a training set of genes known to be involved in a biological process of interest, our approach consists of (i) inferring several models (based on various genomic data sources), (ii) applying each model to the candidate genes to rank those candidates against the profile of the known genes and (iii) merging the several rankings into a global ranking of the candidate genes. In the present article, we describe the latest developments of Endeavour. First, we provide a web-based user interface, besides our Java client, to make Endeavour more universally accessible. Second, we support multiple species: in addition to Homo sapiens, we now provide gene prioritization for three major model organisms: Mus musculus, Rattus norvegicus and Caenorhabditis elegans. Third, Endeavour makes use of additional data sources and is now including numerous databases: ontologies and annotations, protein-protein interactions, cis-regulatory information, gene expression data sets, sequence information and text-mining data. We tested the novel version of Endeavour on 32 recent disease gene associations from the literature. Additionally, we describe a number of recent independent studies that made use of Endeavour to prioritize candidate genes for obesity and Type II diabetes, cleft lip and cleft palate, and pulmonary fibrosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.