Evidence map›Paper›PMID 18508695›Full record

ReviewFrontiers in bioscience : a journal and virtual library2008

Kinetochore structure and spindle assembly checkpoint signaling in the budding yeast, Saccharomyces cerevisiae.

Duncan J Clarke, Jeff Bachant

Open access · bronzeAbstract readReview
In one paragraph

Review in Frontiers in bioscience : a journal and virtual library, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Duncan J ClarkeDepartment of Genetics, Cell Biology and Development, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Jeff Bachant
University of Minnesota Medical Center · US

Funding

Budding Yeast-S-phase Checkpoint ControlR01CA099033 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CLARKE, DUNCAN J · 2003 to 2007
$1.6M
Smt4 Regulation of Centromere Function and CohesionR01GM066190 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BACHANT, JEFF B · 2003 to 2007
$1.4M
NCI NIH HHS CA099033NCI NIH HHS R01 CA099033NIGMS NIH HHS GM-66190
6 · The paper itself

Abstract

The Spindle Assembly Checkpoint (SAC) delays the onset of anaphase until every chromosome is properly bioriented at the spindle equator. Mutations in SAC genes have been found in tumors and compromised SAC function can increase the incidence of some carcinomas in mice, providing further links between cancer etiology, chromosome segregation defects and aneuploidy. Here we review recent developments in our understanding of SAC control with particular emphasis on the role of the kinetochore, the nature of the tension sensing mechanism and the possibility that the SAC encompasses more than just stabilization of securin and/or cyclin-B via inhibition of the APC/C to delay anaphase initiation. Our primary emphasis is on the SAC in the budding yeast Saccharomyces cerevisiae. However, relevant findings in other cells are also discussed to highlight the generally conserved nature of SAC signaling mechanisms.

Indexed as

Cell CycleChromatidsChromatinChromosomes, FungalDNA Topoisomerases, Type IIKinetochoresSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSpindle ApparatusStress, MechanicalChromatinDNA Topoisomerases, Type IISaccharomyces cerevisiae Proteins

Identifiers

PMID18508695
PMCPMC13185079
OpenAlexW1589503710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.