ArticleFrontiers in bioscience : a journal and virtual library2008
Advances in molecular imaging of pancreatic beta cells.
Article in Frontiers in bioscience : a journal and virtual library, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Polymer-Based Nanostructures for Pancreatic Beta-Cell Imaging and Non-Invasive Treatment of Diabetes.Pharmaceutics · 2023Review
- Calcium-dependent ultrasound stimulation of secretory events from pancreatic beta cells.Journal of therapeutic ultrasound · 2017Article
- Combinatorial peptide libraries: mining for cell-binding peptides.Chemical reviews · 2014Review
- Hetero-bivalent GLP-1/glibenclamide for targeting pancreatic β-cells.Chembiochem : a European journal of chemical biology · 2014Article
- SWIFT-CEST: a new MRI method to overcome T₂ shortening caused by PARACEST contrast agents.Magnetic resonance in medicine · 2012Article
- Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27).Diabetologia · 2012Article
- Non-invasive in vivo imaging of pancreatic β-cell function and survival - a perspective.Acta physiologica (Oxford, England) · 2012Review
- T2 exchange agents: a new class of paramagnetic MRI contrast agent that shortens water T2 by chemical exchange rather than relaxation.Magnetic resonance in medicine · 2011Article
- MRI appearance of the pancreas in patients with cystic fibrosis: a comparison of pancreas volume in diabetic and non-diabetic patients.The British journal of radiology · 2010Article
- Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.The Journal of biological chemistry · 2010Article
- Noninvasive imaging of pancreatic beta cells.Nature reviews. Endocrinology · 2009Review
- Advances in beta-cell imaging.European journal of radiology · 2009Review
- Multifunctional magnetic nanocarriers for image-tagged SiRNA delivery to intact pancreatic islets.Transplantation · 2008Article
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Authors and funding
9 authors.
Funding
Abstract
The development of non-invasive imaging methods for early diagnosis of beta cell associated metabolic diseases, including type 1 and type 2 diabetes (T1D and T2D), has recently drawn interest from the molecular imaging community and clinical investigators. Due to the challenges imposed by the location of the pancreas, the sparsely dispersed beta cell population within the pancreas, and the poor understanding of the pathogenesis of the diseases, clinical diagnosis of beta cell abnormalities is still limited. Current diagnostic methods are invasive, often inaccurate, and usually performed post-onset of the disease. Advances in imaging techniques for probing beta cell mass and function are needed to address this critical health care problem. A variety of imaging techniques have been tested for the assessment of pancreatic beta cell islets. Here we discuss current advances in magnetic resonance imaging (MRI), bioluminescence imaging (BLI), and nuclear imaging for the study of beta cell diseases. Spurred by early successes in nuclear imaging techniques for beta cells, especially positron emission tomography (PET), the need for beta cell specific ligands has expanded. Progress for obtaining such ligands is presented. We report our preliminary efforts of developing such a peptidic ligand for PET imaging of pancreatic beta cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.