ReviewFrontiers in bioscience : a journal and virtual library2008
Atherosclerosis as a disease of failed endogenous repair.
Review in Frontiers in bioscience : a journal and virtual library, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Clinical interventions in aging · 2019Trial
- Transient Glycocalyx Remodeling by Intravenous Hyaluronidase in Atherosclerosis: A Hypothesis-Generating Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Cardiovascular effects of approved drugs for rheumatoid arthritis.Nature reviews. Rheumatology · 2021Review
- The Pathogenesis of Atherosclerosis Based on Human Signaling Networks and Stem Cell Expression Data.International journal of biological sciences · 2018Article
- Premature atherosclerosis in premenopausal women: Does cytokine balance play a role?Medical hypotheses · 2017Article
- Expansion and angiogenic potential of mesenchymal stem cells from patients with critical limb ischemia.Journal of vascular surgery · 2017Article
- A Randomized, Controlled Pilot Study of the Effects of Acupuncture on Circulating Endothelial Progenitor Cells in Coronary Heart Disease.Integrative medicine (Encinitas, Calif.) · 2014Article
- Potential beneficial effects of ixmyelocel-T in the treatment of atherosclerotic diseases.Stem cell research & therapy · 2013Article
- Intracavernous administration of bone marrow mononuclear cells: a new method of treating erectile dysfunction?Journal of translational medicine · 2013Review
- Building solutions for cardiovascular disease in women.Texas Heart Institute journal · 2013Article
- Histologic identification of brown adipose and peripheral nerve involvement in human atherosclerotic vessels.Human pathology · 2012Article
- Mononuclear cell therapy reverts cuff-induced thrombosis in apolipoprotein E-deficient mice.Lipids in health and disease · 2012Article
- Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientists.Biology of sex differences · 2011Article
- Systemic inflammation (Interleukin 6) predicts all-cause mortality in men: results from a 9-year follow-up of the MEMO Study.Age (Dordrecht, Netherlands) · 2011Article
- Cell therapy-a 21st century hope for treating cardiovascular disease-a five-year retrospective and predictive view.The American heart hospital journal · 2011Article
- "Gum bug, leave my heart alone!"--epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis.Journal of dental research · 2010Review
- Endothelial progenitor cells and vascular dysfunction in children with obstructive sleep apnea.American journal of respiratory and critical care medicine · 2010Article
- Proceedings from the scientific symposium: Sex differences in cardiovascular disease and implications for therapies.Journal of women's health (2002) · 2010Article
- General overview of the Sixth International Symposium on Stem Cell Therapy and Cardiovascular Innovations.Journal of cardiovascular translational research · 2010Article
- Cardiovascular cell therapy and endogenous repair.Diabetes, obesity & metabolism · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
As coronary artery disease (CAD) continues to be the primary cause of mortality, a more in-depth understanding of pathophysiology and novel treatments are being sought. The past two decades have established inflammation as a driving force behind CAD--from endothelial dysfunction to heart failure. Recent advances in stem/progenitor cell biology have led to initial applications of progenitor cells in CAD continuum and have revealed that atherosclerosis is, at least in part, a disease of failed endogenous vascular repair. Several key progenitor cell populations including endothelial progenitor cells (AC133+/CD34+ population), vascular progenitors (CD31+/CD45(low) population), KDR+ cells and other bone marrow subtypes are mobilized for vascular repair. However, age and risk factors negatively impact these cells even prior to clinical CAD. Sex-based differences in progenitor cell capacity for repair have emerged as a new research focus that may offer mechanistic insights into clinical CAD discrepancies between men and women. Quantifying injury and cell-based repair and better defining their interactions should enable us to halt or even prevent CAD by enhancing the repair side of the repair/injury equation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.