ArticleProceedings of the National Academy of Sciences of the United States of America1991
Bursting electrical activity in pancreatic beta cells caused by Ca(2+)- and voltage-inactivated Ca2+ channels.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Noise-Induced Hearing Loss Enhances CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Deconstructing the integrated oscillator model for pancreatic β-cells.Mathematical biosciences · 2023Article
- Intercellular Communication in the Islet of Langerhans in Health and Disease.Comprehensive Physiology · 2021Article
- Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells.Frontiers in physiology · 2021Review
- Closing in on the Mechanisms of Pulsatile Insulin Secretion.Diabetes · 2018Article
- Time-dependent changes in membrane excitability during glucose-induced bursting activity in pancreatic β cells.The Journal of general physiology · 2011Article
- Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.American journal of physiology. Endocrinology and metabolism · 2010Review
- Toward integration of biological and physiological functions at multiple levels.Frontiers in physiology · 2010Article
- RyR channels and glucose-regulated pancreatic beta-cells.European biophysics journal : EBJ · 2008Article
- The electrophysiology of the beta-cell based on single transmembrane protein characteristics.Biophysical journal · 2007Article
- Effects of both glucose and IP3 concentrations on action potentials in pancreatic beta-cells.European biophysics journal : EBJ · 2007Article
- The phantom burster model for pancreatic beta-cells.Biophysical journal · 2000Article
- Dynamical complexity and temporal plasticity in pancreatic beta-cells.Journal of biosciences · 2000Review
- Neurotransmitters and their receptors in the islets of Langerhans of the pancreas: what messages do acetylcholine, glutamate, and GABA transmit?Endocrine · 1998Review
- Correlations of rates of insulin release from islets and plateau fractions for beta-cells.Bulletin of mathematical biology · 1995Article
- Anti-phase, asymmetric and aperiodic oscillations in excitable cells--I. Coupled bursters.Bulletin of mathematical biology · 1994Article
- Inactivation of voltage-dependent calcium current in an insulinoma cell line.European biophysics journal : EBJ · 1994Article
- Inactivation of HIT cell Ca2+ current by a simulated burst of Ca2+ action potentials.Biophysical journal · 1994Article
- Bursting electrical activity in pancreatic beta-cells: evidence that the channel underlying the burst is sensitive to Ca2+ influx through L-type Ca2+ channels.Pflugers Archiv : European journal of physiology · 1993Article
- Slow voltage inactivation of Ca2+ currents and bursting mechanisms for the mouse pancreatic beta-cell.The Journal of membrane biology · 1992Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigate the hypothesis that two classes of Ca2+ currents, one quickly inactivated by Ca2+ and one slowly inactivated by voltage, contribute to bursting electrical activity in pancreatic islets. A mathematical model of these currents is fit to the experimental whole-cell current-voltage and inactivation profiles, thereby fixing the Ca2+ conductance and all activation and inactivation parameters. Incorporating these currents into a model that includes delayed rectifier K+ channels and ATP-sensitive K+ channels, we show that only abnormal bursting is obtained. Modification of activation parameters to increase Ca2+ channel open times, as suggested by experiment, yields a more robust bursting similar to that observed in intact islets. This reinforces the suggestion that in addition to ATP-sensitive K+ channels, Ca2+ channels may serve as glucose sensors in the beta cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.