Evidence map›Paper›PMID 18508320›Full record

ReviewAmerican journal of hematology2008

Impact of genetic variation on perioperative bleeding.

Jochen D Muehlschlegel, Simon C Body

Open access · greenAbstract readReview
In one paragraph

Review in American journal of hematology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jochen D MuehlschlegelDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. jmuehlschlegel@partners.org
Simon C Body
Brigham and Women's Hospital · US

Funding

Genotypic Impact on Outcomes after CABG SurgeryK23HL068774 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BODY, SIMON C · 2002 to 2006
$803k
NHLBI NIH HHS K23 HL068774
6 · The paper itself

Abstract

Variation in bleeding in the perioperative period is a complex and multifactorial event associated with immediate and delayed consequences for the patient and health care resources. Little is known about the complex genetic influences on perioperative bleeding. With the discovery of multiple variations in the human genome and ever-growing databases of well-phenotyped surgical patients, better identification of patients at risk of bleeding is becoming a reality. In this review, polymorphisms in the platelet receptor genes, plasminogen activator inhibitor, and angiotensin genes among others will be discussed. We will explore the nature, effects, and implications of the genetics that influence perioperative bleeding above and beyond surgical bleeding, particularly in cardiac surgery.

Indexed as

Genetic VariationAngiotensinsBlood Coagulation FactorsBlood Coagulation TestsBlood Loss, SurgicalBlood ProteinsCardiac Surgical ProceduresGenetic Predisposition to DiseaseGenotypeHemorrhagic DisordersHemostasisHumansPlasminogen InactivatorsPlatelet ActivationPolymorphism, GeneticPostoperative HemorrhageAngiotensinsBlood Coagulation FactorsBlood ProteinsPlasminogen Inactivators

Identifiers

PMID18508320
PMCPMC5266599
OpenAlexW2050090131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.