Evidence map›Paper›PMID 18508258›Full record

ReviewCurrent opinion in neurobiology2008

Ena/VASP: proteins at the tip of the nervous system.

Frauke Drees, Frank B Gertler

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 124 citations in OpenAlex.

  1. Emerging roles for E3 ubiquitin ligases in neural development and disease.Frontiers in cell and developmental biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Frauke DreesDavid H Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA.
Frank B Gertler
Massachusetts Institute of Technology · US

Funding

CELLULAR AND DEVELOPMENTAL FUNCTIONS OF MENAR01GM058801 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GERTLER, FRANK B · 1999 to 2012
$3.8M
Cytoskeletal Regulation During Growth Cone Migration and Axon GuidanceR01GM068678 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GERTLER, FRANK B · 2003 to 2012
$2.6M
NIGMS NIH HHS GM 068678NIGMS NIH HHS R01 GM058801NIGMS NIH HHS R01 GM068678
6 · The paper itself

Abstract

The emergence of neurites from a symmetrical cell body is an essential feature of nervous system development. Neurites are the precursors of axons and dendrites and are tipped by growth cones, motile structures that guide elongating axons in the developing nervous system. Growth cones steer the axon along a defined path to its appropriate target in response to guidance cues. This navigation involves the dynamic extension and withdrawal of actin-filled finger-like protrusions called filopodia that continuously sample their environment. Ena/VASP proteins, a conserved family of actin-regulatory proteins, are crucial for filopodia formation and function downstream of several guidance cues. Here we review recent findings into Ena/VASP function in neurite initiation, axon outgrowth and guidance.

Indexed as

Actin CytoskeletonAnimalsCell DifferentiationCuesDNA-Binding ProteinsGrowth ConesHumansNervous SystemNeuritesPseudopodiaStem CellsDNA-Binding ProteinsENA-VASP proteins

Identifiers

PMID18508258
PMCPMC2515615
OpenAlexW2014056363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.