ArticleSchizophrenia research2008
Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia.
Article in Schizophrenia research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- An epigenome-wide association study of early-onset major depression in monozygotic twins.Translational psychiatry · 2020Pooled it
- DNA methylation signatures of treatment response in medication-overuse headache.The journal of headache and pain · 2026Observational
- Protocadherin γC4 regulates neuronal survival and dendritic self-avoidance.Communications biology · 2026Article
- Diversity of clustered protocadherin-α genes in neuronal identity and its role in short-term specific associative memory formation.Scientific reports · 2025Article
- Genetic aetiology of self-harm ideation and behaviour.Scientific reports · 2020Article
- Clustered Protocadherins Emerge as Novel Susceptibility Loci for Mental Disorders.Frontiers in neuroscience · 2020Review
- The difference in serum proteomes in schizophrenia and bipolar disorder.BMC genomics · 2019Article
- Article
- Epigenetic Regulations in Neuropsychiatric Disorders.Frontiers in genetics · 2019Review
- Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.Translational psychiatry · 2018Article
- A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder.Child development · 2018Article
- Article
- Regulation of neural circuit formation by protocadherins.Cellular and molecular life sciences : CMLS · 2017Review
- Nuclear organization and 3D chromatin architecture in cognition and neuropsychiatric disorders.Molecular brain · 2016Review
- High-resolution chromosome ideogram representation of recognized genes for bipolar disorder.Gene · 2016Article
- Article
- Protein Kinase C Phosphorylation of a γ-Protocadherin C-terminal Lipid Binding Domain Regulates Focal Adhesion Kinase Inhibition and Dendrite Arborization.The Journal of biological chemistry · 2015Article
- Symmetrical Dose-Dependent DNA-Methylation Profiles in Children with Deletion or Duplication of 7q11.23.American journal of human genetics · 2015Article
- Association analysis of the Cadherin13 gene with schizophrenia in the Japanese population.Neuropsychiatric disease and treatment · 2015Article
- Olanzapine-induced methylation alters cadherin gene families and associated pathways implicated in psychosis.BMC neuroscience · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Cadherins and protocadherins are cell adhesion proteins that play an important role in neuronal migration, differentiation and synaptogenesis, properties that make them targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Consequently, allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider. One such set of candidate genes is the 5q31-linked PCDH family, which consists of more than 50 exons encoding three related, though distinct family members--alpha, beta, and gamma--which can generate thousands of different protocadherin proteins through alternative promoter usage and cis-alternative splicing. In this study, we focused on a SNP, rs31745, which is located in a putative PCDHalpha enhancer mapped by ChIP-chip using antibodies to covalently modified histone H3. A striking increase in homozygotes for the minor allele at this locus was detected in patients with BD. Molecular analysis revealed that the SNP causes allele-specific changes in binding to a brain protein. The findings suggest that the 5q31-linked PCDH locus should be more thoroughly considered as a disease-susceptibility locus in psychiatric disorders.
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Registered trials
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