ReviewPhysiology & behavior2008
Leptin resistance and the response to positive energy balance.
Review in Physiology & behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Leptin and ghrelin dynamics: unraveling their influence on food intake, energy balance, and the pathophysiology of type 2 diabetes mellitus.Journal of diabetes and metabolic disorders · 2024Review
- Impaired eating behaviors but intact metabolic hormone levels in individuals with major depressive disorder and generalized anxiety disorder.Journal of psychiatric research · 2023Article
- Harnessing the Power of Leptin: The Biochemical Link Connecting Obesity, Diabetes, and Cognitive Decline.Frontiers in aging neuroscience · 2022Review
- Leptin signaling in vagal afferent neurons supports the absorption and storage of nutrients from high-fat diet.International journal of obesity (2005) · 2021Article
- Perinatal exposure to maternal obesity: Lasting cardiometabolic impact on offspring.Prenatal diagnosis · 2020Review
- The unidentified hormonal defense against weight gain.PLoS biology · 2020Article
- High/low cortisol reactivity and food intake in people with obesity and healthy weight.Translational psychiatry · 2020Article
- Article
- Luciferase Reporter Mice forJournal of the Endocrine Society · 2019Article
- Emergence of Leptin in Infection and Immunity: Scope and Challenges in Vaccines Formulation.Frontiers in cellular and infection microbiology · 2018Review
- Life in the fat lane: seasonal regulation of insulin sensitivity, food intake, and adipose biology in brown bears.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Adenovirus 36 and Obesity: An Overview.Viruses · 2015Review
- 20 years of leptin: role of leptin in energy homeostasis in humans.The Journal of endocrinology · 2014Review
- Review
- Rapid onset and reversal of peripheral and central leptin resistance in rats offered chow, sucrose solution, and lard.Appetite · 2013Article
- Leptin resistance does not induce hyperphagia in the rat.The journal of physiological sciences : JPS · 2012Article
- Bidirectional metabolic regulation of neurocognitive function.Neurobiology of learning and memory · 2011Review
- Circulating leptin moderates the effect of stress on snack intake independent of body mass.Eating behaviors · 2010Article
- Article
- Administration of human leptin differentially affects parameters of cortisol secretion in socially housed female rhesus monkeys.Endocrine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Animals readily reduce food intake and normalize body weight following a period of involuntary overfeeding, suggesting that regulatory systems are engaged to defend against excess weight gain. However, these data exist in the background of an ongoing obesity epidemic, where the ready availability of palatable, energy dense foods often leads to obesity. Currently we know very little about the mechanisms underlying the normalization of body weight following involuntary overfeeding, nor do we fully understand why select individuals successfully remain lean despite living in an obesigenic environment. Recent progress in the study of leptin signaling indicates that manipulations which enhance leptin sensitivity reduce food intake and attenuate diet-induced obesity, while reductions in leptin signaling predispose to obesity. While it remains unclear whether a failure or insufficiency in the weight regulatory system contributes to obesity, this work highlights the importance of this system for the regulation of body weight and its potential value for the treatment of obesity. Nonetheless, it is necessary to more clearly identify those mechanisms that protect lean individuals from weight gain and mediate the normalization of body weight that follows involuntary overfeeding, because it is only with this knowledge that we can clearly determine whether obesity is dependent on, or independent of, a failure in the weight regulatory system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.