ArticleNeuropharmacology2008
Calcium release via activation of presynaptic IP3 receptors contributes to kainate-induced IPSC facilitation in rat neocortex.
Article in Neuropharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Formation, Organization, and Maintenance of Synaptic Vesicle Pools: From Molecules to Structure and Dynamics.Advances in neurobiology · 2026Review
- Role of the endoplasmic reticulum in synaptic transmission.Current opinion in neurobiology · 2022Review
- The potential neuroprotective effects of stingless bee honey.Frontiers in aging neuroscience · 2022Review
- New insights into the regulation of synaptic transmission and plasticity by the endoplasmic reticulum and its membrane contacts.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2021Review
- Maintenance of homeostatic plasticity at theeLife · 2019Article
- Trkb-IP3 Pathway Mediating Neuroprotection in Rat Hippocampal Neuronal Cell Culture Following Induction of Kainic Acid.The Malaysian journal of medical sciences : MJMS · 2018Article
- Desensitization-resistant and -sensitive GPCR-mediated inhibition of GABA release occurs by Ca2+-dependent and -independent mechanisms at a hypothalamic synapse.Journal of neurophysiology · 2016Article
- Promoter-Specific Effects of DREADD Modulation on Hippocampal Synaptic Plasticity and Memory Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Organelle-Specific Sensors for Monitoring CaFrontiers in synaptic neuroscience · 2016Review
- Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons.Neuropharmacology · 2015Article
- The effect of aging-associated impaired mitochondrial status on kainate-evoked hippocampal gamma oscillations.Neurobiology of aging · 2012Article
- Activation of alpha1-adrenoceptors enhances glutamate release onto ventral tegmental area dopamine cells.Neuroscience · 2012Article
- Kainate receptor-induced retrograde inhibition of glutamatergic transmission in vasopressin neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Therapeutic potential of kainate receptors.CNS neuroscience & therapeutics · 2011Review
- Presynaptic NMDA receptors mediate IPSC potentiation at GABAergic synapses in developing rat neocortex.PloS one · 2011Article
- Control of intracellular calcium signaling as a neuroprotective strategy.Molecules (Basel, Switzerland) · 2010Review
- Glia-dependent switch of kainate receptor presynaptic action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Proximity of excitatory and inhibitory axon terminals adjacent to pyramidal cell bodies provides a putative basis for nonsynaptic interactions.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Robust short-latency perisomatic inhibition onto neocortical pyramidal cells detected by laser-scanning photostimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- GABA vesicles at synapses: are there 2 distinct pools?The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We examined the mechanisms of kainate (KA) induced modulation of GABA release in rat prefrontal cortex. Pharmacologically isolated IPSCs were recorded from visually identified layer II/III pyramidal cells using whole-cell patch clamp techniques. KA produced an increase in evoked IPSC amplitude at low nanomolar concentrations (100-500 nM). The frequency but not the amplitude of miniature (m) IPSCs was also increased. The GluR5 subunit selective agonist (RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (ATPA) caused an increase in mIPSC frequency whereas (3S,4aR,6S,8aR)-6-(4-carboxyphenyl)methyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid (LY382884), a selective GluR5 subunit antagonist, inhibited this facilitation. Philanthotoxin-433 (PhTx) blocked the effect of KA, indicating involvement of Ca(2+)-permeable GluR5 receptors. No IPSC facilitation was seen when Ca(2+) was omitted from the bathing solution. Facilitation was observed when slices were preincubated in ruthenium red or high concentrations of ryanodine, but was inhibited with application of thapsigargin. The IP3 receptor (IP3R) antagonists diphenylboric acid 2-amino-ethyl ester (2-APB) (15 microM) and Xestospongin C (XeC) blocked IPSC facilitation. These results show that activation of KA receptors (KARs) on GABAergic nerve terminals results is linked to intracellular Ca(2+) release via activation of IP3, but not ryanodine, receptors. This represents a new mechanism of presynaptic modulation whereby Ca(2+) entry through Ca(2+)-permeable GluR5 subunit containing KARs activates IP3Rs receptors leading to an increase in GABA release.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.