ArticleGenome biology2008
Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice.
Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 106 citations in OpenAlex.
- The Expansion of House Mouse Major Urinary Protein Genes Likely Did Not Facilitate Commensalism with Humans.Genes · 2023Article
- Effects of Allergen Exposure and Environmental Risk Factors in Schools on Childhood Asthma.Current allergy and asthma reports · 2023Review
- Regulation of Sexually Dimorphic Expression of Major Urinary Proteins.Frontiers in physiology · 2022Review
- Lymphocytic Choriomeningitis Virus Alters the Expression of Male Mouse Scent Proteins.Viruses · 2021Article
- Molecular complexity of the major urinary protein system of the Norway rat, Rattus norvegicus.Scientific reports · 2019Article
- Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom".Human genomics · 2019Review
- Regulation of volatile and non-volatile pheromone attractants depends upon male social status.Scientific reports · 2019Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- Individual odour signatures that mice learn are shaped by involatile major urinary proteins (MUPs).BMC biology · 2018Article
- Transcriptomic and Proteomic Profiling Revealed High Proportions of Odorant Binding and Antimicrobial Defense Proteins in Olfactory Tissues of the House Mouse.Frontiers in genetics · 2018Article
- Allergen and Epitope Targets of Mouse-Specific T Cell Responses in Allergy and Asthma.Frontiers in immunology · 2018Article
- Differential regulation of vaginal lipocalins (OBP, MUP) during the estrous cycle of the house mouse.Scientific reports · 2017Article
- Glareosin: a novel sexually dimorphic urinary lipocalin in the bank vole,Open biology · 2017Article
- Molecular heterogeneity in major urinary proteins of Mus musculus subspecies: potential candidates involved in speciation.Scientific reports · 2017Article
- Characterisation of urinary WFDC12 in small nocturnal basal primates, mouse lemurs (Microcebus spp.).Scientific reports · 2017Article
- Olfactory effects of a hypervariable multicomponent pheromone in the red-legged salamander, Plethodon shermani.PloS one · 2017Article
- On the tear proteome of the house mouse (PeerJ · 2017Article
- Diversity of major urinary proteins (MUPs) in wild house mice.Scientific reports · 2016Article
- Regulation of highly homologous major urinary proteins in house mice quantified with label-free proteomic methods.Molecular bioSystems · 2016Article
- On the saliva proteome of the Eastern European house mouse (Mus musculus musculus) focusing on sexual signalling and immunity.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe major urinary proteins (MUPs) of Mus musculus domesticus are deposited in urine in large quantities, where they bind and release pheromones and also provide an individual 'recognition signal' via their phenotypic polymorphism. Whilst important information about MUP functionality has been gained in recent years, the gene cluster is poorly studied in terms of structure, genic polymorphism and evolution.
resultsWe combine targeted sequencing, manual genome annotation and phylogenetic analysis to compare the Mup clusters of C57BL/6J and 129 strains of mice. We describe organizational heterogeneity within both clusters: a central array of cassettes containing Mup genes highly similar at the protein level, flanked by regions containing Mup genes displaying significantly elevated divergence. Observed genomic rearrangements in all regions have likely been mediated by endogenous retroviral elements. Mup loci with coding sequences that differ between the strains are identified--including a gene/pseudogene pair--suggesting that these inbred lineages exhibit variation that exists in wild populations. We have characterized the distinct MUP profiles in the urine of both strains by mass spectrometry. The total MUP phenotype data is reconciled with our genomic sequence data, matching all proteins identified in urine to annotated genes.
conclusionOur observations indicate that the MUP phenotypic polymorphism observed in wild populations results from a combination of Mup gene turnover coupled with currently unidentified mechanisms regulating gene expression patterns. We propose that the structural heterogeneity described within the cluster reflects functional divergence within the Mup gene family.
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