ArticleCell division2008
The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond.
Article in Cell division, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Engineered chromatin readers track damaged chromatin dynamics in live cells and animals.Nature communications · 2025Article
- CCAR2 controls mitotic progression through spatiotemporal regulation of Aurora B.Cell death & disease · 2022Article
- Increased Aurora B expression reduces substrate phosphorylation and induces chromosomal instability.Frontiers in cell and developmental biology · 2022Article
- TAS-119, a novel selective Aurora A and TRK inhibitor, exhibits antitumor efficacy in preclinical models with deregulated activation of the Myc, β-Catenin, and TRK pathways.Investigational new drugs · 2021Article
- Survivin regulates chromosome segregation by modulating the phosphorylation of Aurora B during porcine oocyte meiosis.Cell cycle (Georgetown, Tex.) · 2018Article
- Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation.Trends in genetics : TIG · 2017Review
- Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell.Journal of experimental & clinical cancer research : CR · 2016Article
- Article
- Aurora Kinase A Is Upregulated in Cutaneous T-Cell Lymphoma and Represents a Potential Therapeutic Target.The Journal of investigative dermatology · 2015Article
- Aurora B expression and histone variant H1.4S27 phosphorylation are no longer coordinated during metaphase in aneuploid colorectal carcinomas.Virchows Archiv : an international journal of pathology · 2015Article
- Signalling dynamics in the spindle checkpoint response.Nature reviews. Molecular cell biology · 2014Review
- Interplay between the DNA damage proteins MDC1 and ATM in the regulation of the spindle assembly checkpoint.The Journal of biological chemistry · 2014Article
- Chromosome segregation in plant meiosis.Frontiers in plant science · 2014Review
- Phosphorylation regulates kinase and microtubule binding activities of the budding yeast chromosomal passenger complex in vitro.The Journal of biological chemistry · 2013Article
- A role for p38 in transcriptional elongation of p21 (CIP1) in response to Aurora B inhibition.Cell cycle (Georgetown, Tex.) · 2013Article
- Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis.Molecular biology of the cell · 2012Article
- Kalanchoe tubiflora extract inhibits cell proliferation by affecting the mitotic apparatus.BMC complementary and alternative medicine · 2012Article
- Spindle assembly checkpoint: the third decade.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- The potential role of Aurora kinase inhibitors in haematological malignancies.British journal of haematology · 2011Review
- Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis.Journal of cell science · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essential prerequisite for the equal segregation of chromosomes. The spindle assembly checkpoint can prevent chromosome segregation as long as not all chromosome pairs have obtained bipolar attachment to the spindle. The chromosomal passenger complex plays a crucial role during chromosome alignment by correcting faulty chromosome-spindle interactions (e.g. attachments that do not generate tension). In the process of doing so, the chromosomal passenger complex generates unattached chromosomes, a specific situation that is known to promote checkpoint activity. However, several studies have implicated an additional, more direct role for the chromosomal passenger complex in enforcing the mitotic arrest imposed by the spindle assembly checkpoint. In this review, we discuss the different roles played by the chromosomal passenger complex in ensuring proper mitotic checkpoint function. Additionally, we discuss the possibility that besides monitoring the presence of unattached kinetochores, the spindle assembly checkpoint may also be capable of responding to chromosome-microtubule interactions that do not generate tension and we propose experimental set-ups to study this.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.