ArticleJournal of viral hepatitis2008
The inverse relationship between chronic HBV and HCV infections among injection drug users is associated with decades of age and drug use.
Article in Journal of viral hepatitis, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Risk of window period HIV infection in high infectious risk donors: systematic review and meta-analysis.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2011Pooled it
- Socio-demographic association with confirmed hepatitis C virus infection: A cross-sectional analysis from a teaching institute.Journal of family medicine and primary care · 2024Article
- Prevalence of Hepatitis B Virus Infection Among US Adults Aged 20-59 Years With a History of Injection Drug Use: National Health and Nutrition Examination Survey, 2001-2016.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Systematic Review and Meta-Analysis of Global Prevalence of HBsAg and HIV and HCV Antibodies among People Who Inject Drugs and Female Sex Workers.Pathogens (Basel, Switzerland) · 2020Review
- Toward a more accurate estimate of the prevalence of hepatitis C in the United States.Hepatology (Baltimore, Md.) · 2015Article
- Clinical significance of circulating miR-122 in patients with dual chronic hepatitis B and C virus infection.Hepatology international · 2015Article
- Subgroup differences in response to 8 weeks of ledipasvir/sofosbuvir for chronic hepatitis C.Open forum infectious diseases · 2014Article
- Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver.Journal of virology · 2014Article
- HCV RNA levels in a multiethnic cohort of injection drug users: human genetic, viral and demographic associations.Hepatology (Baltimore, Md.) · 2012Article
- Epidemiology of hepatitis C virus infection & liver disease among injection drug users (IDUs) in Chennai, India.The Indian journal of medical research · 2010Article
- Comparing respondent-driven sampling and targeted sampling methods of recruiting injection drug users in San Francisco.Journal of urban health : bulletin of the New York Academy of Medicine · 2010Article
- Acceptability of a safer injection facility among injection drug users in San Francisco.Drug and alcohol dependence · 2010Article
- Genetic variation in CLDN1 and susceptibility to hepatitis C virus infection.Journal of viral hepatitis · 2010Article
- More rare birds, and the occasional swan.Gastroenterology · 2009Article
- MBL2 and hepatitis C virus infection among injection drug users.BMC infectious diseases · 2008Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
Infection with hepatitis C virus (HCV) may suppress co-infection with hepatitis B virus (HBV) during acute or chronic HBV infection. We examined relationships between HBV infection, HCV infection and other factors among injection drug users (IDUs) with antibodies to both viruses. Participants enrolled in a cross-sectional study during 1998-2000 were considered to have been infected with HBV if they had core antibody, to be chronically infected if they had hepatitis B surface antigen (HBsAg), to have been infected with HCV if they had HCV antibody and to be chronically infected if they had HCV RNA. Among 1694 participants with antibody to both viruses, HBsAg prevalence decreased with increasing age among those positive for HCV RNA [from 4.55% in those 18-29 years to 1.03% in those >or=50 years old (P(trend) = 0.02)], but not among those who were negative for HCV RNA. Chronic HBV infection was less common overall among those with chronic HCV infection (odds ratio [OR], 0.25; P < 0.0001), but this inverse relationship was much stronger in the oldest (>50 years; OR = 0.15) than the youngest (18-29 years; OR = 0.81) participants (P(trend) = 0.03). Similar results were obtained when duration of injection drug use was substituted for age (P(trend) = 0.05). Among IDUs who have acquired both HBV and HCV, chronic HBV infection is much less common among those with chronic HCV infection, but this inverse relationship increases markedly with increasing years of age and injection drug use. Co-infection with HCV may enhance the resolution of HBsAg during the chronic phases of these infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.