Trial reportBritish journal of clinical pharmacology2008
Dose-effect study of domperidone as a galactagogue in preterm mothers with insufficient milk supply, and its transfer into milk.
Trial report in British journal of clinical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03221855 (Randomized Clinical Trial), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Clinical Trial: Use of Domperidone to Increase Milk Production in Mothers With Newborns Hospitalized in Neonatology
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis.Clinical drug investigation · 2016Pooled it
- Medications for increasing milk supply in mothers expressing breastmilk for their preterm hospitalised infants.The Cochrane database of systematic reviews · 2012Pooled it
- Efficacy of Wang Nam Yen herbal tea on human milk production: A randomized controlled trial.PloS one · 2022Trial
- Recombinant human prolactin for the treatment of lactation insufficiency.Clinical endocrinology · 2010Trial
- SUpporting Mothers Milk Intervention Trial (SUMMIT) - a randomised controlled trial comparing different doses of domperidone for treating lactation insufficiency in mothers of preterm infants - study protocol.International breastfeeding journal · 2026Article
- Breastfeeding Counseling Practices Among Plastic Surgeons: Results From a National Survey.Plastic and reconstructive surgery. Global open · 2025Article
- Drugs in Human Milk Part 1: Practical and Analytical Considerations in Measuring Drugs and Metabolites in Human Milk.Clinical pharmacokinetics · 2024Review
- Women's experiences with using domperidone as a galactagogue to increase breast milk supply: an australian cross-sectional survey.International breastfeeding journal · 2023Article
- Review
- Association between Domperidone Administered via Feeding Tube and Feeding Success in Critically Ill Patients with Enteral Feeding Intolerance.Journal of personalized medicine · 2021Article
- Sialylated human milk oligosaccharides prevent intestinal inflammation by inhibiting toll like receptor 4/NLRP3 inflammasome pathway in necrotizing enterocolitis rats.Nutrition & metabolism · 2021Article
- What Evidence Do We Have for Pharmaceutical Galactagogues in the Treatment of Lactation Insufficiency?-A Narrative Review.Nutrients · 2019Review
- Supporting Mothers of Very Preterm Infants and Breast Milk Production: A Review of the Role of Galactogogues.Nutrients · 2018Review
- Should Domperidone be Used as a Galactagogue? Possible Safety Implications for Mother and Child.Drug safety · 2017Article
- Maternal experiences with and sources of information on galactagogues to support lactation: a cross-sectional study.International journal of women's health · 2017Article
- Feasibility and Acceptability of Two Complementary and Alternative Therapies for Perceived Insufficient Milk in Mothers of Late Preterm and Early Term Infants.Alternative & complementary therapies : a new bimonthly publication for health care practitioners · 2016Article
- Effect of Domperidone in 2nd week Postpartum on Milk Output in Mothers of Preterm Infants.Indian journal of pediatrics · 2016Article
- A Review of Herbal and Pharmaceutical Galactagogues for Breast-Feeding.Ochsner journal · 2016Review
- Health provider experiences with galactagogues to support breastfeeding: a cross-sectional survey.Journal of multidisciplinary healthcare · 2016Article
- Nipple Pain in Breastfeeding Mothers: Incidence, Causes and Treatments.International journal of environmental research and public health · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate the possibility of a dose-response relationship for the use of domperidone in treating insufficient milk supply in mothers of preterm infants, and to quantify the exposure of the breastfed infant to domperidone.
methodsSix preterm mothers received domperidone (30 mg daily or 60 mg daily) in a double-blind, randomized, crossover trial. Milk production and serum prolactin were measured before and during the trial, and domperidone concentration in milk was measured during drug treatment.
resultsFor milk production, two of the mothers were 'nonresponders', whereas the other four were 'responders' and showed a significant increase in milk production from 8.7 +/- 3.1 g h(-1) in the run-in phase (mean +/- SEM), 23.6 +/- 3.9 g h(-1) for the 30-mg dose (P = 0.0217) and 29.4 +/- 6.6 g h(-1) for the 60-mg dose (P = 0.0047). In all participants, serum prolactin was significantly increased for both doses, but the response was not dose dependent. Median (interquartile range) domperidone concentrations in milk over a dose interval at steady-state were 0.28 microg l(-1) (0.24-0.43) and 0.49 microg l(-1) (0.33-0.72) for the 30-mg and 60-mg doses, respectively. The mean relative infant dose was 0.012% at 30 mg daily and 0.009% at 60 mg daily.
conclusionIn one-third of mothers, domperidone did not increase milk production. In the remainder, milk production increased at both domperidone doses, and there was a trend for a dose-response relationship. The amount of domperidone that transfers into milk was extremely low, and infant exposure via breastfeeding was not considered to be significant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.